Evidence map›Paper›PMID 40229536›Full record

ReviewBone marrow transplantation2025

How we treat mantle cell lymphoma with cellular therapy in 2025: the European and American perspectives.

Peter Dreger, Sairah Ahmed, Ali Bazarbachi, Sascha Dietrich, Timothy S Fenske, Nilanjan Ghosh, Olivier Hermine, Mehdi Hamadani

Abstract readReview
In one paragraph

Review in Bone marrow transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Peter DregerDepartment Medicine V, University of Heidelberg, Heidelberg, Germany. peter.dreger@med.uni-heidelberg.de.ORCID http://orcid.org/0000-0002-7429-8570
Sairah AhmedDepartment of Lymphoma and Myeloma, University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID http://orcid.org/0000-0001-7302-8299
Ali BazarbachiBone Marrow Transplantation Program, Department of Internal Medicine, American University of Beirut, Beirut, Lebanon.ORCID http://orcid.org/0000-0002-7171-4997
Sascha DietrichUniversity Hospital Düsseldorf, Department of Hematology, Oncology and Clinical Immunology, Düsseldorf, Germany.
Timothy S FenskeSarah Cannon Transplant and Cellular Therapy Program, Methodist Hospital, San Antonio, TX, USA.
Nilanjan GhoshAtrium Health Levine Cancer Institute, Wake Forest University School of Medicine, Charlotte, NC, USA.
Olivier HermineDepartment of Adult Hematology, Necker Hospital, Université de Paris-Cité, Assistance Publique des Hôpitaux de Paris, Imagine Institute, INSERM U1183, Paris, France.
Mehdi HamadaniDivision of Hematology & Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID http://orcid.org/0000-0001-5372-510X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cellular therapies have been cornerstones of the treatment of mantle cell lymphoma (MCL) for decades and have helped to improve the outcome of this formerly very unfavourable B-cell lymphoma considerably. Current established roles of cellular therapies include autologous hematopoietic cell transplantation (HCT) as part of first-line therapy, chimeric antigen receptor-engineered T-cells (CART) for relapsed/refractory MCL, and allogeneic HCT for settings in which CARTs have failed or are unavailable. Therapeutic innovations have recently entered the MCL treatment landscape and are moving upstream in treatment algorithms, challenging the existing management principles. The purpose of this paper is to give some guidance regarding how to best use cellular therapies in this increasingly complex environment. Due to differences in CART labels, available non-cellular treatment options, and philosophy between the American and the European health systems, we found it reasonable to contrast the American and European perspectives on defined standard scenarios, which are often overlapping but show discrepancies in some important aspects.

Indexed as

Cell- and Tissue-Based TherapyHematopoietic Stem Cell TransplantationLymphoma, Mantle-CellEuropeHumansUnited States

Identifiers

PMID40229536
PMCPMC12151868

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.