ArticleEuropean journal of pediatrics2025
Septo-optic dysplasia and gastroschisis: trends in birth prevalence and association with maternal age.
Article in European journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aims to describe the risk factors and trends in birth prevalence of septo-optic dysplasia (SOD) and gastroschisis between 1980 and 2023. This descriptive, population-based study of SOD and gastroschisis used Western Australian Register of Developmental Anomalies data from 1980 to 2023. Birth prevalence was calculated using Midwives Notification System data for all births after 20 weeks gestation. Relative risk (RR) for SOD and gastroschisis showed risk by maternal age. SOD and gastroschisis occurred in 99 and 391 cases respectively (no dual diagnoses), with a birth prevalence of 1.41 and 3.71 per 10,000 respectively (from 2010 to 2019), and have been stable since 2010. For the study period, younger maternal age (under 25 years old) increased the risk of SOD and gastroschisis (RR, 3.28 [95% confidence interval (CI) 2.13-5.00]; RR, 4.50 [95% CI 3.68-5.49] respectively). From 2010 to 2023, median maternal age increased for SOD and gastroschisis by 4.8 years (p = 0.044) to 27.0 and by 2.8 years (p < 0.001) to 25.5, respectively. Mothers living in areas of greater socioeconomic disadvantage had higher risk (RR, 1.81 [95% CI 1.14-2.88] in SOD and RR, 1.41 [95% CI 1.06-1.86] in gastroschisis), independent of maternal age. Premature birth was more common in children with SOD and gastroschisis.
conclusionWhile younger mothers are more likely to have a child with either SOD or gastroschisis, maternal age at birth is higher than reported in the literature and is rising. This is probably attributable to the rising age of mothers at delivery, and further research into risk factors beyond maternal age is recommended. WHAT IS KNOWN: • Septo-optic dysplasia and gastroschisis are both rare diseases, known to occur more commonly in younger mothers. • Maternal age at birth is increasing in high income countries. WHAT IS NEW: • Despite mean maternal age rising in both conditions, in-line with rising population maternal age, birth prevalence is stable. • Mothers living in areas of greater socioeconomic disadvantage had a higher relative risk of SOD and gastroschisis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.