ArticleNature biomedical engineering2025
An implantable hydrogel-based phononic crystal for continuous and wireless monitoring of internal tissue strains.
Article in Nature biomedical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Multimodal smart suture for dynamic postoperative wound monitoring.Bioactive materials · 2026Article
- Tailored construction and functional applications of conductive hydrogels for bioelectronic interfaces.Discover nano · 2026Review
- Materials-Structure-Hardware-Algorithm Co-Driven Hierarchical Optimization for Flexible Sensors.Nano-micro letters · 2026Review
- Integrated Ultrasonic Platform for Bioelectronic Control through Biological Barriers Based on Metasurface.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Ultrasound-responsive composite hydrogels: Design rules for spatiotemporally controlled drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2026Review
- Mechanical Training-Induced Restructuring Enables Self-Extendability and Mechanical Consistency in Organohydrogels.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Article
- Bandgap-enabled ultrasound tissue marking by a biodegradable metastructured hydrogel implant.Science advances · 2026Article
- Bioresorbable acoustic patch for simultaneous sealing and early detection of gastric leakage.Science advances · 2026Article
- High-strength liquid metal composite-hydrogel interfaces enable robust stretchable electronics.Nature communications · 2026Article
- Development of MWCNTs/MXene/PVA Hydrogel Electrochemical Sensor for Multiplex Detection of Wound Infection Biomarkers.Micromachines · 2026Article
- Physical Intelligence in Small-Scale Robots and Machines.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Thermo-responsive, on-demand adhesive and tissue-conformal hydrogel electrodes for organ repair and brain-computer interfaces.Materials today. Bio · 2026Article
- Flexible Polymer-Based Electronics for Human Health Monitoring: A Safety-Level-Oriented Review of Materials and Applications.Nano-micro letters · 2026Review
- The cutting-edge advancements in biomaterials under the guidance of intelligence and bionics.Regenerative biomaterials · 2026Review
- Spatially Programmable Electroadhesive Enables In Situ Site-Selective Functional Coupling.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Biodegradable ultrasound contrast tape for tracing intestinal motility.Nature communications · 2025Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
Conventional implantable electronic sensors for continuous monitoring of internal tissue strains are yet to match the biomechanics of tissues while maintaining biodegradability, biocompatibility and wireless monitoring capability. Here we present a two-dimensional phononic crystal composed of periodic air columns in soft hydrogel, which was named ultrasonic metagel, and we demonstrate its use as implantable sensor for continuous and wireless monitoring of internal tissue strains. The metagel's deformation shifts its ultrasonic bandgap, which can be wirelessly detected by an external ultrasonic probe. We demonstrate ex vivo the ability of the metagel sensor for monitoring tissue strains on porcine tendon, wounded tissue and heart. In live pigs, we further demonstrate the ability of the metagel to monitor tendon stretching, respiration and heartbeat, working stably during 30 days of implantation, and we loaded the metagel with growth factors to achieve different healing rates in subcutaneous wounds. The metagel results almost completely degraded 12 weeks after implantation. Our finding highlights the clinical potential of the ultrasonic sensor for tendon rehabilitation monitoring and drug delivery efficacy evaluation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.