SynthesisScientific reports2025
Systematic review and meta-analysis of the effects of blood flow restriction training on bone health in older adults.
Synthesis in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The Effectiveness of Blood Flow Restriction Training on Rehabilitation After Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While low-intensity blood flow restriction (LI-BFR) training has recently been shown to improve bone health, there remains limited evidence regarding its impact on older adults. This meta-analysis aimed to quantitatively identify the effects of LI-BFR training on bone mineral density (BMD) and bone biomarkers compared with conventional resistance training programs. Studies were identified through searches of four databases: PubMed, Scopus, SPORTDiscus, and Web of Science. R packages were utilized for this meta-analysis. The results indicated that compared to low-intensity (LI) training, LI-BFR significantly increased BMD (ES = 0.25, 95% Confidence Interval [CI]: [0.08, 0.41], p < 0.01), osteotropic hormones (i.e., GH, ES = 1.18, 95%CI: [0.66, 1.70]), p < 0.001; IGF-1, ES = 0.89, 95% CI: [0.44, 1.33], p < 0.001), but resulted in a smaller increase in bone resorption markers (i.e., CTX, ES = -0.77, 95%CI: [-1.16, -0.37], p < 0.001). LI-BFR training demonstrated similar effects on BMD improvement as high-intensity (HI) resistance training (ES = -0.1, 95%CI: [-0.66, 0.41], p = 0.64). Furthermore, sex and training frequency moderated the secretion of osteotropic hormones (male vs. female: IGF-1, 0.51 vs. 1.64, p < 0.01; ≤ 3 times per week vs. > 3 times per week: GH, 1.62 vs. 0.68, p < 0.01, and IGF-1, 1.13 vs. 0.39, p < 0.05). In conclusion, LI-BFR training shows promise for enhancing bone health in older adults, offering benefits comparable to HI training.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.