Evidence map›Paper›PMID 40229388›Full record

ArticleScientific reports2025

Circulating citrate as a mediator in the relationship between HMGCR inhibitors and chronic hepatitis B: a Mendelian randomization study.

Lili Zhang, Yuming Li, Ying Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lili ZhangDepartment of Ultrasonography, The First Hospital of Jilin University, 1 Xinmin Street, Changchun, 130021, Jilin, People's Republic of China.
Yuming LiDepartment of Advanced Mathematics, Basic Department, Jilin College of Commerce and Industry, No. 1666, Kalun Lake Street, Jiutai Economic Development Zone, Changchun, 130021, Jilin, People's Republic of China.
Ying LiDepartment of Neonatology, Children's Medical Center, The First Hospital of Jilin University, 1 Xinmin Street, Changchun, 130021, Jilin, People's Republic of China. liying66@jlu.edu.cn.

Funding

Jilin Provincial Department of Finance 2018SCZWSZX-052
6 · The paper itself

Abstract

Observational studies have found that HMGCR inhibitors can be used to treat chronic viral hepatitis. In this study, to explore the potential mechanism of HMGCR inhibitors in treating Chronic hepatitis B (CHB), two-sample and two-step Mendelian randomization (MR) were used to investigate the causal relationship between HMGCR inhibitors and the mediating role of circulating metabolites. GWAS data of expression quantitative trait loci eQTLs of HMGCR inhibitors, 168 circulating metabolites, CHB, and myocardial infarction were obtained from the IEUOpenGWAS project. Random effects inverse-variance weighted (IVW) was the main causal analysis method, and the MR-Egger regression method was used as a supplementary analysis method. Cochran's Q test and I

Indexed as

CitratesHepatitis B, ChronicHydroxymethylglutaryl-CoA Reductase InhibitorsGenome-Wide Association StudyHumansMendelian Randomization AnalysisMyocardial InfarctionPolymorphism, Single NucleotideQuantitative Trait LociCitratesHydroxymethylglutaryl-CoA Reductase InhibitorsChronic hepatitis BCirculating metabolitesHydroxymethylglutaryl-CoA reductase inhibitorsMendelian randomization

Identifiers

PMID40229388
PMCPMC11997182

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.