Evidence map›Paper›PMID 40229319›Full record

ArticleScientific reports2025

Chiral symmetry breaking and information accumulation in pre-biological protocell evolution.

Konstantin K Konstantinov, Alisa F Konstantinova

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Konstantin K KonstantinovSoftellect Systems, Inc., 414-300 Ave des Sommets, Verdun, QC, H3E 2B7, Canada. konstantin@softellect.net.ORCID http://orcid.org/0000-0002-4851-5850
Alisa F KonstantinovaSoftellect Systems, Inc., 414-300 Ave des Sommets, Verdun, QC, H3E 2B7, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We study a linear evolutionary model based on the two-dimensional distribution of protocells by total enantiomeric excess and the amount of stored information, which they can pass from generation to generation, and without any mutual inhibition. We show that the evolution of such systems occurs in four distinct stages. The first stage is an exponential growth of the concentration of protocells near the point [Formula: see text] and it should take negligible time on a geological scale. The second stage is a diffusion-like process in both dimensions. This process can also be accompanied by a drift in the direction of increased information passed from generation to generation, provided that the appropriate linear coefficient in the information storage subspace is large enough. The third stage is a rapid symmetry breaking and formation of the species near [Formula: see text] value of enantiomeric excess (assuming a small positive global enantiomeric asymmetry factor). The fourth stage is a relaxation toward a global stationary point, which is a narrow peak located near [Formula: see text] value of enantiomeric excess and some optimal value of the amount of stored information.

Indexed as

Biological information storageChiral symmetry breakingMolecular evolution

Identifiers

PMID40229319
PMCPMC11997073

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.