ArticleNature communications2025
Stereo olfaction underlies stable coding of head direction in blind mice.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Ecological Visual Processing in the Mouse.Annual review of neuroscience · 2026Review
- Simultaneous path-integration recalibration in head direction and place cells.Current biology : CB · 2026Article
- Global research trends and hotspot evolution of olfactory dysfunction from 2014 to 2024: a bibliometric analysis.Annals of medicine and surgery (2012) · 2026Review
- Synchronized path-integration recalibration but distinct landmark-control dynamics in head direction and CA1 place cells.bioRxiv : the preprint server for biology · 2025Article
- Encoding of interdependent features of head direction and angular head velocity in navigation.PNAS nexus · 2025Article
- Stereo olfaction underlies stable coding of head direction in blind mice.Nature communications · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stereo olfaction, the difference in odor concentration between the two nostrils, has been shown to affect a variety of animal behaviors, including olfactory search. However, it is unknown whether stereo olfaction can enable the formation of allocentric spatial representations. Here, recording from head direction (HD) cells in the anterior dorsal nucleus of the thalamus in blind mice-a model system for studying olfaction-dependent allocentric spatial representations-we find that inhibiting stereo olfaction, by blocking olfactory processing in one nostril or merging the airflow going to both nostrils, drastically impairs head direction coding. To assess the behavioral impact of impaired HD cell tuning caused by loss of stereo olfaction, we developed a closed-loop head direction preference assay, in which a mouse received medial forebrain bundle reward stimulation upon orientating its head in a specific direction. We find that inhibiting stereo olfaction significantly impairs performance in the HD preference assay. These results reveal that stereo olfaction is required for mice to use smell to form a stable allocentric spatial representation of head direction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.