ArticleNature communications2025
GABAergic neurons in central amygdala contribute to orchestrating anxiety-like behaviors and breathing patterns.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Defining Clock Neurons Within Distributed Circadian Circuits Through Multiscale Technologies.Journal of biological rhythms · 2026Review
- A projection atlas of excitatory and inhibitory inputs to the preBötzinger complex: substrates for multimodal breathing control.Journal of neurophysiology · 2026Article
- Perioperative Anxiety in Adults: A Narrative Review of Pathophysiology, Assessment, and Multimodal Management Strategies.Healthcare (Basel, Switzerland) · 2026Review
- GABAergic Inhibition from the Nucleus Tractus Solitarius to Ventrolateral Medulla Phox2b Neurons Modulates Central Respiratory Chemoreflex and Ventilatory Homeostasis.Neuroscience bulletin · 2026Article
- Article
- Respiratory-Limbic Coupling via a Thalamic Circuit Alleviates Anxiety.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Corticotropin releasing hormone-expressing inputs to the thalamic paraventricular nucleus: pathways from mother to memory?Neurobiology of stress · 2026Article
- The pPVTThe journal of headache and pain · 2026Article
- 7T multimodal MRI reveals structural-functional-quantitative susceptibility mapping abnormalities of new daily persistent headache.The journal of headache and pain · 2025Article
- Effects of Noise Stress on Neuronal Activation in Rat Auditory Pathway-Related Brain Regions.Diagnostics (Basel, Switzerland) · 2025Article
- Counterbalancing O-GlcNAcylation and STAT3 Phosphorylation in Ventral Tegmental Area Dopaminergic Neurons Mediates Behavioral Adaptations to Acute Restraint Stress.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Multiple mediators of anxiety and depression between living space and cognitive function among elderly patients with ischemic stroke.Frontiers in psychiatry · 2025Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Anxiety is characterized by dysregulated respiratory reactivity to emotional stimuli. The central amygdala (CeA) is a pivotal structure involved in processing emotional alterations, but its involvement in orchestrating anxiety-like behaviors and specific breathing patterns remains largely unexplored. Our findings demonstrate that the acute restraint stress (ARS) induces anxiety-like behaviors in mice, marked by prolonged grooming time and faster respiratory frequency (RF). Conversely, silencing GABAergic CeA neurons reduces post-ARS anxiety-like behaviors, as well as the associated increases in grooming time and RF. In actively behaving mice, stimulation of GABAergic CeA neurons elicits anxiety-like behaviors, concurrently prolongs grooming time, accelerates RF through a CeA-thalamic paraventricular nucleus (PVT) circuit. In either behaviorally quiescent or anesthetized mice, stimulation of these neurons significantly increases RF but does not induce anxiety-like behaviors through the CeA-lateral parabrachial nucleus (LPBN) circuit. Collectively, GABAergic CeA neurons are instrumental in orchestrating anxiety-like behaviors and breathing patterns primarily through the CeA-PVT and CeA-LPBN circuits, respectively.
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