ArticleNature communications2025
MGAT1-Guided complex N-Glycans on CD73 regulate immune evasion in triple-negative breast cancer.
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Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12citing papers in PubMed
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Who cites it
12 citing papers in PubMed.
- AURKB-mediated phosphorylation of metabolic enzyme CD73 drives immune suppression and renal cell carcinoma progression.Cell death and differentiation · 2026Article
- DruGUI 2.0: mapping protein druggability with probe-based molecular dynamics.Bioinformatics (Oxford, England) · 2026Article
- Immune implications and therapeutic opportunities of tumor glycosylation.Nature cancer · 2026Review
- Glucose metabolic reprogramming as a driver of immunosuppression in the tumour microenvironment.Clinical and translational medicine · 2026Review
- Article
- Metabolic immune checkpoints in cancer: how tumor-derived metabolites shape immunotherapy resistance.Frontiers in immunology · 2026Review
- Adenosine signaling in tumor immune escape: metabolic checkpoints, myeloid suppression, and combination immunotherapy.Frontiers in oncology · 2026Review
- In Situ Assembly of Transformable Monopeptide on Activated Neutrophils Attenuates NETs-Induced Hepatocellular Carcinoma Metastasis by Disrupting NE Nuclear Translocation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- O-glycosylation in Cancer: Emerging Paradigms and Prospects for Precision Oncology.International journal of biological sciences · 2026Review
- The RNA-Binding Protein RBMX Mediates the Immunosuppressive Microenvironment of Osteosarcoma by Regulating CD8Cancers · 2025Article
- Effect of Platelet-Derived Microparticles on the Expression of Adhesion Molecules in Endothelial Cells.International journal of molecular sciences · 2025Article
- Editorial: Deciphering cell-cell interactions in triple-negative breast cancer.Frontiers in immunology · 2025Article
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Authors and funding
24 authors.
Junlong Jack Chi *Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, USA.
Ping Xie *Department of Medicine, Robert H. Lurie Comprehensive Cancer Center, Northwestern, University Feinberg School of Medicine, Chicago, IL, USA.
Mary Hongying Cheng *Laufer Center for Physical & Quantitative Biology, Stony Brook University, Stony Brook, NY, USA.ORCID http://orcid.org/0000-0001-5833-8221
Yueming ZhuDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, USA.
Xin CuiDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, USA.
Joshua WatsonDepartment of Biochemistry and Molecular Biology and Institute of Bioinformatics, University of Georgia, Athens, USA.ORCID http://orcid.org/0009-0006-5455-8810
Lidan ZengDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0001-8445-7451
Amad UddinDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, USA.
Hoang NguyenLaufer Center for Physical & Quantitative Biology, Stony Brook University, Stony Brook, NY, USA.ORCID http://orcid.org/0000-0002-0251-3147
Lei LiDepartment of Chemistry, Georgia State University, Atlanta, USA.ORCID http://orcid.org/0000-0002-1146-0761
Kelley MoremenComplex Carbohydrate Research Center, University of Georgia, Athens, USA.ORCID http://orcid.org/0000-0003-1768-582X
April ReedyDepartment of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0001-7484-1986
Megan WyattWinship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0003-1316-260X
Adam MarcusWinship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.
Mingji DaiWinship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0001-7956-6426
Chrystal M PaulosWinship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-0784-2601
Massimo CristofanilliDepartment of Medicine, Weill Cornell Medicine, New York, NY, USA.
William J GradisharDepartment of Medicine, Robert H. Lurie Comprehensive Cancer Center, Northwestern, University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-2772-3140
Shaying ZhaoDepartment of Biochemistry and Molecular Biology and Institute of Bioinformatics, University of Georgia, Athens, USA.ORCID http://orcid.org/0000-0001-5852-9570
Kevin KalinskyWinship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-3113-7902
Mine-Chie HungGraduate Institute of Biomedical Sciences, Institute of Biochemistry and Molecular Biology, Cancer Biology and Precision Therapeutics Center, and Center for Molecular Medicine, China Medical University, Taichung, Taiwan.ORCID http://orcid.org/0000-0003-4317-4740
Ivet BaharLaufer Center for Physical & Quantitative Biology, Stony Brook University, Stony Brook, NY, USA. bahar@laufercenter.org.ORCID http://orcid.org/0000-0001-9959-4176
Bin ZhangDepartment of Medicine, Robert H. Lurie Comprehensive Cancer Center, Northwestern, University Feinberg School of Medicine, Chicago, IL, USA. bin.zhang@northwestern.edu.ORCID http://orcid.org/0000-0002-6631-7647
Yong WanDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, USA. yong.wan@emory.edu.
Funding
Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9MWinship Cancer Institute Cancer Center Support GrantP30CA138292 · NCI · EMORY UNIVERSITY · PI Ragini Reiney Kudchadkar · 2009 to 2026
$47.5MTreating AT Deficiency with Drugs that Modulate the Proteostasis NetworkP01DK096990 · NIDDK · WASHINGTON UNIVERSITY · PI PERLMUTTER, DAVID H · 2012 to 2023
$18.3MTR&D 7: Cell Specific ProteomicsP41GM108569 · NIGMS · NORTHWESTERN UNIVERSITY · PI KELLEHER, NEIL L · 2015 to 2024
$13.6MTargeting posttranslational modifications of CD73 in TNBCsR01CA258857 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Yong Wan, Bin Zhang · 2021 to 2026
$3.2MToward a Deeper Understanding of Allostery and Allotargeting by Computational ApproachesR01GM139297 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Ivet Bahar · 2021 to 2026
$2.8MrPIV5- and AVLP-vectored vaccine development with public tumor-specific neoantigensR01CA252713 · NCI · UNIVERSITY OF GEORGIA · PI HILDEBRAND, WILLIAM, ZHAO, SHAYING · 2021 to 2025
$2.6MTargeting posttranslational modifications of B7-H4 in carcinogenesis and therapyR01CA258765 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Yong Wan · 2021 to 2026
$2.5MThe distinct role of cysteinyl leukotriene receptor for myeloid-derived suppressive cellsR01CA250101 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ZHANG, BIN · 2020 to 2025
$2.5MTargeting Posttranslational Modifications in Breast CarcinogenesisR01CA250110 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WAN, YONG · 2020 to 2025
$2.3MWEE1 inhibition and tumor immunityR01CA222963 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ZHANG, BIN · 2018 to 2023
$2.2MInterplay between ER and TGF-b in carcinogenesisR01CA202948 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WAN, YONG · 2016 to 2021
$1.4MNCI NIH HHS P30 CA060553NCI NIH HHS P30 CA138292NCI NIH HHS R01 CA202948NCI NIH HHS R01 CA222963NCI NIH HHS R01 CA250101NCI NIH HHS R01 CA250110NCI NIH HHS R01 CA252713NCI NIH HHS R01 CA258765NCI NIH HHS R01 CA258857NIDDK NIH HHS P01 DK096990NIGMS NIH HHS P41 GM108569NIGMS NIH HHS R01 GM139297U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R01CA202948U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R01CA250110U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R01CA258765U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R01CA258857
Abstract
Despite the widespread application of immunotherapy, treating immune-cold tumors remains a significant challenge in cancer therapy. Using multiomic spatial analyses and experimental validation, we identify MGAT1, a glycosyltransferase, as a pivotal factor governing tumor immune response. Overexpression of MGAT1 leads to immune evasion due to aberrant elevation of CD73 membrane translocation, which suppresses CD8
Indexed as
5'-NucleotidaseGlycosyltransferasesImmune EvasionN-AcetylglucosaminyltransferasesPolysaccharidesTriple Negative Breast NeoplasmsTumor EscapeAnimalsCD8-Positive T-LymphocytesCell Line, TumorFemaleGlycosylationGPI-Linked ProteinsHumansMice5'-NucleotidaseGlycosyltransferasesGPI-Linked ProteinsN-AcetylglucosaminyltransferasesNT5E protein, humanPolysaccharides
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.