Evidence map›Paper›PMID 40229280›Full record

ArticleNature communications2025

Genome-wide association study identifies common variants associated with breast cancer in South African Black women.

Mahtaab Hayat, Wenlong C Chen, Chantal Babb de Villiers, Sang Hyuck Lee, Charles Curtis, Rob Newton, Tim Waterboer, Freddy Sitas, Debbie Bradshaw, Mazvita Muchengeti and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Integrating multi-omics data for next-generation cancer research and precision medicine.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Mahtaab Hayat *Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. mahtaab.hayat@wits.ac.za.ORCID http://orcid.org/0000-0003-4723-1407
Wenlong C Chen *Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID http://orcid.org/0000-0002-3248-4906
Chantal Babb de VilliersDivision of Human Genetics, National Health Laboratory Service and School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID http://orcid.org/0000-0003-1334-1819
Sang Hyuck LeeSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Charles CurtisSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Rob NewtonMRC/UVRI and LSHTM Uganda Research Unit, Entebbe, Uganda.
Tim WaterboerInfections and Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0002-0616-6963
Freddy SitasBurden of Disease Research Unit, South African Medical Research Council, Cape Town, South Africa.
Debbie BradshawBurden of Disease Research Unit, South African Medical Research Council, Cape Town, South Africa.
Mazvita MuchengetiNational Cancer Registry, National Health Laboratory Service, Johannesburg, South Africa.ORCID http://orcid.org/0000-0002-1955-923X
Elvira SinghNational Cancer Registry, National Health Laboratory Service, Johannesburg, South Africa.
Cathryn M LewisSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-8249-8476
Michele RamsaySydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID http://orcid.org/0000-0002-4156-4801
Christopher G MathewSydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID http://orcid.org/0000-0003-4178-1838
Jean-Tristan BrandenburgSydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. jean-tristan.brandenburg@wits.ac.za.ORCID http://orcid.org/0000-0003-0197-2648

Funding

RCUK | Medical Research Council (MRC) MRCRFA-SHIP 01-2015
6 · The paper itself

Abstract

Genome-wide association studies (GWAS) have characterized the contribution of common variants to breast cancer (BC) risk in populations of European ancestry, however GWAS have not been reported in resident African populations. This GWAS included 2485 resident African BC cases and 1101 population matched controls. Two risk loci were identified, located between UNC13C and RAB27A on chromosome 15 (rs7181788, p = 1.01 × 10

Indexed as

Black PeopleBreast NeoplasmsGenetic Predisposition to DiseaseAdultCase-Control StudiesChromosomes, Human, Pair 17FemaleGenome-Wide Association StudyHumansMiddle AgedMultifactorial InheritancePolymorphism, Single Nucleotiderab GTP-Binding ProteinsSouth AfricaThiolester HydrolasesWhite Peoplerab GTP-Binding ProteinsThiolester Hydrolases

Identifiers

PMID40229280
PMCPMC11997036

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.