Evidence map›Paper›PMID 40229242›Full record

ReviewCell death & disease2025

Phosphoinositide signaling at the cytoskeleton in the regulation of cell dynamics.

Xiaoting Hou, Yu Chen, Noah D Carrillo, Vincent L Cryns, Richard A Anderson, Jichao Sun, Songlin Wang, Mo Chen

Abstract readReview
In one paragraph

Review in Cell death & disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaoting Hou *Department of Pharmacology, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen, China.ORCID http://orcid.org/0009-0007-7649-4122
Yu Chen *Department of Pharmacology, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Noah D CarrilloDepartment of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Vincent L CrynsDepartment of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0003-0355-2268
Richard A AndersonUniversity of Wisconsin Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0001-6265-8359
Jichao SunDepartment of Pharmacology, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen, China.ORCID http://orcid.org/0000-0002-7671-2157
Songlin WangDepartment of Pharmacology, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen, China. wangsl@sustech.edu.cn.ORCID http://orcid.org/0000-0002-7435-2637
Mo ChenDepartment of Pharmacology, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen, China. chenm7@sustech.edu.cn.ORCID http://orcid.org/0000-0002-3274-5889

Funding

Phosphoinositide Signaling in the Cytosol and NucleusR35GM134955 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Richard A. Anderson · 2020 to 2026
$5.0M
Regulation of Nuclear Akt by p53, MDM2 and Phosphoinositide Lipids Roles in Oncogenic Transformation and Tumor ProgressionR01CA286492 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Richard A. Anderson, VINCENT L. CRYNS · 2024 to 2026
$2.8M
National Natural Science Foundation of China (National Science Foundation of China) 32400577NCI NIH HHS R01 CA286492NIGMS NIH HHS R35 GM134955
6 · The paper itself

Abstract

The cytoskeleton, composed of microfilaments, intermediate filaments, and microtubules, provides the structural basis for cellular functions such as motility and adhesion. Equally crucial, phosphoinositide (PIP

Indexed as

CytoskeletonPhosphatidylinositolsSignal TransductionAnimalsHumansMicrotubulesPhosphatidylinositols

Identifiers

PMID40229242
PMCPMC11997203

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.