Evidence map›Paper›PMID 40229205›Full record

ArticleChemistry & biodiversity2025

Staphylococcus aureus AgrA Modulators From South African Antimicrobial Plants.

Christiana Eleojo Aruwa, Saheed Sabiu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Christiana Eleojo AruwaDepartment of Biotechnology and Food Science, Faculty of Applied Sciences, Durban University of Technology, Durban, KwaZulu-Natal, South Africa.ORCID https://orcid.org/0000-0003-4979-8968
Saheed SabiuDepartment of Biotechnology and Food Science, Faculty of Applied Sciences, Durban University of Technology, Durban, KwaZulu-Natal, South Africa.ORCID https://orcid.org/0000-0001-7209-9220

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

South African plants are an underutilized metabolite source for novel antimicrobials targeting key quorum sensing (QS) systems like the Staphylococcus aureus AgrA. AgrA-modulating metabolites constitute a new approach to reducing resistance development. This study created a library of 1211 metabolites from 266 South African plants with antimicrobial action. Metabolites' anti-QS activities were assessed using advanced computational methods. Molecular docking showed top five metabolites (hinokiflavone, asphodelin, elliptinone, mamegakinone, and robustaflavone). Most leads conformed to the Lipinski's rule of 5. Dynamics simulation revealed closest ∆G

Indexed as

Anti-Bacterial AgentsBacterial ProteinsStaphylococcus aureusMicrobial Sensitivity TestsMolecular Docking SimulationMolecular StructureQuorum SensingSouth AfricaStructure-Activity RelationshipAnti-Bacterial AgentsBacterial ProteinsAgrADynamics simulationFingerprintingQuorum sensingVirtual screening

Identifiers

PMID40229205
PMCPMC12435411

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.