Evidence map›Paper›PMID 40228898›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025

Functional Heterogeneity within the Primate Ventral Striatum for Motivational Regulation.

Haruhiko Iwaoki, Yukiko Hori, Yuki Hori, Koki Mimura, Kei Oyama, Yuji Nagai, Toshiyuki Hirabayashi, Ken-Ichi Inoue, Masahiko Takada, Makoto Higuchi and 1 more

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Circuit-Based Approaches to Understanding the Anterior Cingulate Cortex (ACC).The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Haruhiko IwaokiAdvanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan.
Yukiko HoriAdvanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan.
Yuki HoriAdvanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan.
Koki MimuraAdvanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan.
Kei OyamaAdvanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan.
Yuji NagaiAdvanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan.
Toshiyuki HirabayashiAdvanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan.
Ken-Ichi InoueSystems Neuroscience Section, Center for the Evolutionary Origins of Human Behavior, Kyoto University, Aichi 484-8506, Japan.
Masahiko TakadaSystems Neuroscience Section, Center for the Evolutionary Origins of Human Behavior, Kyoto University, Aichi 484-8506, Japan.ORCID https://orcid.org/0000-0003-0774-2333
Makoto HiguchiAdvanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan.
Takafumi MinamimotoAdvanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan minamimoto.takafumi@qst.go.jp.ORCID https://orcid.org/0000-0003-4305-0174

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ventral striatum (VS) is a key brain region for reward processing and motivation, and its dysfunctions have been implicated in psychiatric disorders such as apathy and obsessive-compulsive disorder. Although functional heterogeneity within the VS has been well established in rodents, its relevance and mechanisms in primates remain unclear. To address this issue, we performed bilateral pharmacological inactivation of the VS in two male macaque monkeys using muscimol, a GABA

Indexed as

MotivationVentral StriatumAnimalsGABA-A Receptor AgonistsMacaca mulattaMagnetic Resonance ImagingMaleMuscimolRewardGABA-A Receptor AgonistsMuscimolcheckingmonkeymotivationmuscimolrestingventral striatum

Identifiers

PMID40228898
PMCPMC12096147

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.