Evidence map›Paper›PMID 40228867›Full record

ArticleeNeuro2025

Electrical Stimulation of the M1 Activates Somatostatin Interneurons in the S1: Potential Mechanisms Underlying Pain Suppression.

Junhee Park, Yong Geon Kim, Taehyeon Kim, Myungin Baek

Abstract read
In one paragraph

Article in eNeuro, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Junhee ParkDepartment of Brain Sciences, DGIST, Daegu 42988, Republic of Korea.
Yong Geon KimDepartment of Brain Sciences, DGIST, Daegu 42988, Republic of Korea.
Taehyeon KimDepartment of Brain Sciences, DGIST, Daegu 42988, Republic of Korea.
Myungin BaekDepartment of Brain Sciences, DGIST, Daegu 42988, Republic of Korea bmi008@dgist.ac.kr.ORCID https://orcid.org/0000-0001-8906-901X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic pain affects millions globally, yet no universally effective treatment exists. The primary motor cortex (M1) has been a key target for chronic pain therapies, with electrical stimulation of the M1 (eMCS) showing promise. However, the mechanisms underlying M1-mediated analgesic effects are not fully understood. We investigated the role of the primary somatosensory cortex (S1) in M1-mediated analgesia using a neuropathic pain mouse model. In this model, neuropathic pain is associated with increased spontaneous activity of layer V pyramidal neurons (LV-PNs) in the S1, partly attributed to the reduced activity of somatostatin-expressing inhibitory neurons (SST

Indexed as

InterneuronsMotor CortexNeuralgiaSomatosensory CortexSomatostatinAnimalsDisease Models, AnimalElectric StimulationMaleMiceMice, Inbred C57BLPyramidal CellsSomatostatinanalgesic effectelectrical stimulationneuropathic painprimary motor cortexprimary somatosensory cortexsomatostatin interneurons

Identifiers

PMID40228867
PMCPMC12043047

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.