Evidence map›Paper›PMID 40228864›Full record

ArticleLife science alliance2025

STAT5B leukemic mutations, altering SH2 tyrosine 665, have opposing impacts on immune gene programs.

Hye Kyung Lee, Jichun Chen, Rachael L Philips, Sung-Gwon Lee, Xingmin Feng, Zhijie Wu, Chengyu Liu, Aaron B Schultz, Molly Dalzell, Manja Meggendorfer and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. STAT3 SH2 Domain Aspartic Acid 661 Mutations Activate Immune Gene Programs.Journal of cellular and molecular medicine · 2026
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Hye Kyung LeeLaboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health, Bethesda, MD, USA hyekyung.lee@nih.gov.
Jichun ChenHematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-1038-471X
Rachael L PhilipsMolecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
Sung-Gwon LeeLaboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health, Bethesda, MD, USA.
Xingmin FengHematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-8018-2366
Zhijie WuHematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-3984-0819
Chengyu LiuTransgenic Core, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, MD, USA.
Aaron B SchultzDepartment of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL, USA.
Molly DalzellDepartment of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL, USA.
Manja MeggendorferMunich Leukemia Laboratory (MLL) Max-Lebsche-Platz 31, München, Germany.
Claudia HaferlachMunich Leukemia Laboratory (MLL) Max-Lebsche-Platz 31, München, Germany.
Foster BirnbaumDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-6062-2296
Joel A SextonDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Amy E KeatingDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
John J O'SheaMolecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
Neal S YoungHematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Alejandro V VillarinoDepartment of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL, USA.
Priscilla A FurthLaboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health, Bethesda, MD, USA hyekyung.lee@nih.gov.ORCID 0000-0003-3883-0715
Lothar HennighausenLaboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health, Bethesda, MD, USA lotharh@nih.gov.ORCID 0000-0001-8319-9841

Funding

Tumor Biology Research ProgramP30CA240139 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Stephen D. Nimer · 2019 to 2026
$24.1M
Graduate Training in Computational and Systems BiologyT32GM087237 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BURGE, CHRISTOPHER B · 2009 to 2023
$4.6M
Computational and Experimental Investigation and Design of Protein Interaction SpecificityR35GM149227 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI AMY E KEATING · 2023 to 2026
$2.2M
Predoctoral Training in Translational ImmunologyT32AI162624 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Thomas R Malek · 2022 to 2026
$894k
Intramural Research Programs (IRPs) of National Heart, Lung, and Blood Institute (NHLBI)Intramural Research Programs (IRPs) of National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)Intramural Research Programs (IRPs) of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NCI NIH HHS P30 CA240139NIAID NIH HHS T32 AI162624NIGMS NIH HHS R35 GM149227NIGMS NIH HHS T32 GM087237
6 · The paper itself

Abstract

STAT5B is a vital transcription factor for lymphocytes. Here, the function of two STAT5B mutations from human T-cell leukemias: one substituting tyrosine 665 with phenylalanine (STAT5B

Indexed as

Leukemia, T-CellSTAT5 Transcription FactorAnimalsCD8-Positive T-LymphocytesHumansMiceMutationPhosphorylationTyrosineSTAT5B protein, humanStat5b protein, mouseSTAT5 Transcription FactorTyrosine

Identifiers

PMID40228864
PMCPMC11999048

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.