Evidence map›Paper›PMID 40228524›Full record

ArticleNature2025

PRDM16-dependent antigen-presenting cells induce tolerance to gut antigens.

Liuhui Fu, Rabi Upadhyay, Maria Pokrovskii, Francis M Chen, Gabriela Romero-Meza, Adam Griesemer, Dan R Littman

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed.

  1. Review
  2. Article
  3. Intestinal uptake regulates T cell responses to dietary antigens.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Intestinal muscularis in health and disease.Communications biology · 2026
    Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Liuhui Fu *Department of Cell Biology, New York University School of Medicine, New York, NY, USA.ORCID 0000-0003-4108-3220
Rabi Upadhyay *Department of Cell Biology, New York University School of Medicine, New York, NY, USA.ORCID 0000-0002-2154-0132
Maria Pokrovskii *Department of Cell Biology, New York University School of Medicine, New York, NY, USA.
Francis M ChenDepartment of Cell Biology, New York University School of Medicine, New York, NY, USA.ORCID 0000-0002-6615-4155
Gabriela Romero-MezaDepartment of Cell Biology, New York University School of Medicine, New York, NY, USA.
Adam GriesemerNYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA.ORCID 0000-0003-4894-2024
Dan R LittmanDepartment of Cell Biology, New York University School of Medicine, New York, NY, USA. dan.littman@med.nyu.edu.ORCID 0000-0002-2850-8688

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARK Reid PHILIPS · 1985 to 2026
$83.1M
Determinants of induced Treg and inflammatory Th17 cell balance in response to potentially pathogenic microbiotaR01AI158687 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Dan Littman · 2021 to 2026
$3.2M
Harnessing human gut-derived Bacteroides to drive systemic anti-tumor immunityK08CA283272 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Rabi Upadhyay · 2024 to 2026
$845k
Investigating a RORgt-expressing antigen presenting cell required for peripheral Treg responses to gut microbiotaF32AI181496 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Francis M Chen · 2024 to 2026
$154k
NCI NIH HHS K08 CA283272NCI NIH HHS P30 CA016087NIAID NIH HHS F32 AI181496NIAID NIH HHS R01 AI158687
6 · The paper itself

Abstract

The gastrointestinal tract is continuously exposed to foreign antigens in food and commensal microorganisms with potential to induce adaptive immune responses. Peripherally induced T regulatory (pT

Indexed as

Antigen-Presenting CellsAntigensDNA-Binding ProteinsImmune ToleranceTranscription FactorsAnimalsCell DifferentiationDendritic CellsFemaleGastrointestinal MicrobiomeMaleMiceMice, Inbred C57BLNuclear Receptor Subfamily 1, Group F, Member 3T-Lymphocytes, RegulatoryAntigensDNA-Binding ProteinsNuclear Receptor Subfamily 1, Group F, Member 3Prdm16 protein, mouseRorc protein, mouseTranscription Factors

Identifiers

PMID40228524
PMCPMC12176658

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.