Evidence map›Paper›PMID 40228414›Full record

ArticleJournal of neurosurgery. Case lessons2025

Rapid resolution of depression and epilepsy following resection of a septal region tumor: illustrative case.

Clara Kwon Starkweather, Leo P Sugrue, Pierre Nedelec, Andrew D Krystal, Robert C Knowlton, Edward F Chang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurosurgery. Case lessons, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Clara Kwon StarkweatherDepartment of Neurological Surgery, University of California, San Francisco, California.
Leo P SugrueDepartment of Radiology, University of California, San Francisco, California.
Pierre NedelecDepartment of Radiology, University of California, San Francisco, California.ORCID 0000-0002-8535-1541
Andrew D KrystalDepartment of Psychiatry, University of California, San Francisco, California.
Robert C KnowltonDepartment of Neurology, University of California, San Francisco, California.
Edward F ChangDepartment of Neurological Surgery, University of California, San Francisco, California.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe authors present a case of a young patient who presented with depression symptoms and epilepsy. She was found to have a low-grade glioneuronal tumor located in the septal region, a critical limbic area involved in neuropsychiatric disorders. This region includes the ventral striatum, a key component of the brain's reward processing circuitry, which has been targeted in deep brain stimulation trials for treatment-resistant depression. OBSERVATIONS: Following resection of the septal region tumor, the patient experienced rapid remission of both her depression symptoms and epilepsy. LESSONS: This case illustrates the resolution of both seizures and mood disturbances following the removal of the septal region tumor and highlights the potential for lesions in key limbic structures to underlie both disruption of mood and epileptic activity. https://thejns.org/doi/10.3171/CASE24733.

Indexed as

depressionepilepsyseptal regionventral striatum

Identifiers

PMID40228414
PMCPMC12001057

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.