ArticlePLOS digital health2025
Association of the child opportunity index with in-hospital mortality and persistence of organ dysfunction at one week after onset of Phoenix Sepsis among children admitted to the pediatric intensive care unit with suspected infection.
Article in PLOS digital health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Contextual nonmedical health factors and critical care-related outcomes: a systematic review.Critical care (London, England) · 2025Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The social determinants of health (SDoH) are fundamental factors that contribute to overall health and health-related outcomes. Children living in lower socioeconomic areas have a higher risk of critical illness and worse outcomes compared to children living in more socioeconomically advantaged areas. In this work, we determine whether the Child Opportunity Index (COI 3.0), a multi-dimensional child-specific indicator of neighborhood environment, is associated with in-hospital mortality or persistence of a Phoenix Sepsis Score ≥ 2 at one week following Phoenix Sepsis onset in children admitted to pediatric intensive care units (PICUs) with suspected infection. We performed a retrospective cohort analysis of 63,824 patients with suspected or confirmed infection admission diagnosis in two PICUs in Atlanta, Georgia with a Georgia residential address that could be geocoded and linked to a census tract. The primary outcome was the composite of in-hospital mortality or persistence of a Phoenix Sepsis Score ≥ 2 at one week following Phoenix Sepsis onset. Model performance measures of interest were the area under the receiver operating characteristic curve (AUROC) and the area under the precision-recall curve (AUPRC). Models developed with electronic medical record (EMR) data using Egleston (EG) or Scottish Rite (SR) as the training site achieved AUROCs of 0.81-0.84 (95% CI range: 0.8-0.85) and 0.82-0.82 (95% CI range: 0.81-0.83) and AUPRCs of 0.59-0.68 (95% CI range: 0.58-0.69) and 0.62-0.64 (95% CI range: 0.61-0.65) respectively. Despite significant differences in COI 3.0 characteristics and overall in-hospital mortality of children with Phoenix suspected infection between the EG and SR PICUs, the addition of COI 3.0 did not improve the overall model performance metrics. While children admitted to both PICUs were more often from COI 3.0 neighborhoods in the lowest two quintiles, these neighborhood features had less of an impact on the model's predictive performance compared to patient physiologic and biologic features available in the EMR.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.