Evidence map›Paper›PMID 40228184›Full record

ArticleNeurology2025

Deciphering the Natural History of

Jan H Magielski, Stacey Cohen, Michael C Kaufman, Shridhar Parthasarathy, Julie Xian, Elise Brimble, Nasha Fitter, Francesca Furia, Elena Gardella, Rikke Steensbjerre Møller and 2 more

Abstract read
In one paragraph

Article in Neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. CharacterizingmedRxiv : the preprint server for health sciences · 2026
    Article
  3. Article
  4. Article
  5. Infantile epileptic spasms syndrome: Mechanisms and therapeutic approaches.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jan H MagielskiDivision of Neurology, Children's Hospital of Philadelphia, PA.ORCID 0000-0001-7290-4939
Stacey CohenDivision of Neurology, Children's Hospital of Philadelphia, PA.
Michael C KaufmanDivision of Neurology, Children's Hospital of Philadelphia, PA.ORCID 0000-0003-2718-296X
Shridhar ParthasarathyDivision of Neurology, Children's Hospital of Philadelphia, PA.
Julie XianDivision of Neurology, Children's Hospital of Philadelphia, PA.ORCID 0000-0002-0205-0648
Elise BrimbleCitizen Health, San Francisco, CA.
Nasha FitterCitizen Health, San Francisco, CA.
Francesca FuriaDepartment of Epilepsy Genetics and Personalized Treatment, The Danish Epilepsy Center, Dianalund, Denmark.
Elena GardellaDepartment of Epilepsy Genetics and Personalized Treatment, The Danish Epilepsy Center, Dianalund, Denmark.ORCID 0000-0002-7138-6022
Rikke Steensbjerre MøllerDepartment of Epilepsy Genetics and Personalized Treatment, The Danish Epilepsy Center, Dianalund, Denmark.ORCID 0000-0002-9664-1448
Ingo HelbigDivision of Neurology, Children's Hospital of Philadelphia, PA.ORCID 0000-0001-8486-0558
Jillian L McKeeDivision of Neurology, Children's Hospital of Philadelphia, PA.ORCID 0000-0001-9724-0403

Funding

Subgroup delineation in genetic epilepsies and developmental brain disordersR01NS127830 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI Ingo Helbig · 2023 to 2026
$2.8M
NINDS NIH HHS R01 NS127830
6 · The paper itself

Abstract

BACKGROUND AND

objectives

methodsIn this study, we harmonized electronic medical record data from 82 individuals with

resultsCompared with the cohort of other known or presumed genetic epilepsies, those with DISCUSSION:

Indexed as

EpilepsyNAV1.6 Voltage-Gated Sodium ChannelAdolescentChildChild, PreschoolCohort StudiesFemaleGain of Function MutationHumansInfantMalePhenotypeSeizuresNAV1.6 Voltage-Gated Sodium ChannelSCN8A protein, human

Identifiers

PMID40228184
PMCPMC11998016

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.