Evidence map›Paper›PMID 40228146›Full record

ArticleOrganic letters2025

Translation of Nickel-Catalyzed C(sp

Brett D Akana-Schneider, Julianna M Mouat, Sisi Zhang, Michelle E Akana, Bin Wu, Daniel J Weix

Abstract read
In one paragraph

Article in Organic letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Brett D Akana-SchneiderDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.ORCID 0000-0002-2249-3809
Julianna M MouatDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.ORCID 0000-0002-3976-3676
Sisi ZhangChemical & Analytical Development, Suzhou Novartis Technical Development Company Limited, Changshu, Jiangsu 215537, China.
Michelle E AkanaDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.ORCID 0000-0002-1148-7059
Bin WuChemical & Analytical Development, Suzhou Novartis Technical Development Company Limited, Changshu, Jiangsu 215537, China.ORCID 0000-0002-9761-2139
Daniel J WeixDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.ORCID 0000-0002-9552-3378

Funding

Reductive Coupling Reactions: Trading Organometallic Reagents for Organic HalidesR01GM097243 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Daniel John Weix · 2011 to 2026
$5.6M
Catalytic Redox Reactions for Pharmaceutical SynthesisR35GM134929 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Shannon S Stahl · 2020 to 2026
$4.3M
QExactive (Orbitrap) mass spectrometerS10OD020022 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI VESTLING, MARTHA M · 2015 to 2015
$483k
NIGMS NIH HHS R01 GM097243NIGMS NIH HHS R35 GM134929NIH HHS S10 OD020022
6 · The paper itself

Abstract

The cross-electrophile coupling of organobromides is widely utilized in organic synthesis but generally requires undesirable amide solvents (e.g., DMF, DMA, and NMP). We report that the combination of a strongly donating, bidentate nitrogen ligand, LiI, and 4-picoline enables coupling in a variety of alcohol, ester, and ethereal solvents at up to 50 g scale. An improved synthesis of the optimal ligand, 4,4'-bis(dimethylamino)-2,2'-bipyridine, is also reported on the basis of the reductive homocoupling of 4-dimethylamino-2-chloropyridine.

Identifiers

PMID40228146
PMCPMC12094182

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.