Evidence map›Paper›PMID 40228073›Full record

ArticleMagnetic resonance in medicine2025

When CEST meets diffusion: Multi-echo diffusion-encoded CEST (dCEST) MRI to measure intracellular and extracellular CEST signal distributions.

Sultan Z Mahmud, Hye-Young Heo

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Dynamic glucose-enhanced MRI in brain tumors.Magma (New York, N.Y.) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sultan Z MahmudDepartment of Radiology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Hye-Young HeoDepartment of Radiology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0002-7297-2015

Funding

TRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Hanzhang Lu, Peter CM Van Zijl · 2021 to 2026
$9.9M
Ultrafast Quantitative pH MRI for Acute Ischemic Stroke PatientsR01NS112242 · NINDS · JOHNS HOPKINS UNIVERSITY · PI HEO, HYE YOUNG · 2020 to 2024
$1.9M
Chemical Exchange Saturation Transfer MR FingerprintingR01EB029974 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI HEO, HYE YOUNG · 2021 to 2024
$1.4M
NIBIB NIH HHS P41 EB031771NIBIB NIH HHS R01 EB029974NIH HHSNIH HHS P41EB031771NIH HHS R01EB029974NIH HHS R01NS112242NINDS NIH HHS R01 NS112242
6 · The paper itself

Abstract

purposeTo develop a multi-echo, diffusion-encoded chemical exchange saturation transfer (dCEST) imaging technique for estimating the intracellular and extracellular/intravascular contributions to the conventional CEST signal.

methodsA dCEST pulse sequence was developed to quantify the signal fractions, transverse relaxation times (T

resultsThe multi-echo diffusion results showed that the intracellular water fractions were significantly higher than the extracellular water fractions, whereas the intracellular T

conclusionsThe dCEST imaging technique provides valuable insight into the source of signals in conventional CEST MRI, offering potential utility for clinical applications.

Indexed as

BrainDiffusion Magnetic Resonance ImagingImage Processing, Computer-AssistedAdultAlgorithmsFemaleHealthy VolunteersHumansMaleYoung AdultAPTCESTdiffusionDWIintracellular and extracellular compartments

Identifiers

PMID40228073
PMCPMC12202737

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.