Evidence map›Paper›PMID 40228067›Full record

ArticleCirculation2025

G-Protein-Coupled Estrogen Receptor 1 and Pregnancy Confer Protection Against Hypertension in Older Females.

Ravneet Singh, Supaporn Kulthinee, Victoria L Nasci, Elvis A Akwo, Chibundu Juliet Umunna, Rawan N Almutlaq, Oleh M Pochynyuk, Cassianne Robinson-Cohen, Eman Y Gohar

Abstract readLetter
In one paragraph

Article in Circulation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. GPER1 activation regulates renal purinergic P2YAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ravneet Singh *Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN (R.S., S.K., V.L.N., E.A.A., C.J.U., C.R.-C., E.Y.G.).
Supaporn Kulthinee *Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN (R.S., S.K., V.L.N., E.A.A., C.J.U., C.R.-C., E.Y.G.).
Victoria L NasciDivision of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN (R.S., S.K., V.L.N., E.A.A., C.J.U., C.R.-C., E.Y.G.).ORCID 0000-0002-1891-8974
Elvis A AkwoDivision of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN (R.S., S.K., V.L.N., E.A.A., C.J.U., C.R.-C., E.Y.G.).
Chibundu Juliet UmunnaDivision of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN (R.S., S.K., V.L.N., E.A.A., C.J.U., C.R.-C., E.Y.G.).
Rawan N AlmutlaqDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham (R.N.A.).ORCID 0009-0009-1342-1860
Oleh M PochynyukDepartment of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston (O.M.P.).ORCID 0000-0002-5397-6897
Cassianne Robinson-CohenDivision of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN (R.S., S.K., V.L.N., E.A.A., C.J.U., C.R.-C., E.Y.G.).ORCID 0000-0003-4783-7046
Eman Y GoharDivision of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN (R.S., S.K., V.L.N., E.A.A., C.J.U., C.R.-C., E.Y.G.).ORCID 0000-0003-0988-6445

Funding

Significance of Epac signaling in renal Na+handling and hypertensionR01DK136462 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI XIAODONG CHENG, Oleh Pochynyuk · 2024 to 2026
$2.0M
Unraveling the Impact of Estrogen Signaling on Postmenopausal HypertensionR01HL171122 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eman Gohar · 2024 to 2026
$1.8M
Physiology of ClC-K2/b Cl- channel in the collecting ductR01DK117865 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI POCHYNYUK, OLEH · 2019 to 2023
$1.7M
Sex Differences in Renal Sodium HandlingR00DK119413 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GOHAR, EMAN · 2021 to 2023
$740k
NHLBI NIH HHS R01 HL171122NIDDK NIH HHS R00 DK119413NIDDK NIH HHS R01 DK117865NIDDK NIH HHS R01 DK136462
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

agingaldosteroneblood pressurekidneysodium

Identifiers

PMID40228067
PMCPMC11999251

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.