Evidence map›Paper›PMID 40227803›Full record

ArticleJournal of cellular physiology2025

Mechanism of MCUB-Dependent Inhibition of Mitochondrial Calcium Uptake.

Neeraj K Rai, David R Eberhardt, Anthony M Balynas, Melissa J S MacEwen, Ashley R Bratt, Yasemin Sancak, Dipayan Chaudhuri

Abstract read
In one paragraph

Article in Journal of cellular physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Mitochondrial Calcium Signaling in Hepatocyte Health and Disease.Cold Spring Harbor perspectives in biology · 2026
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Neeraj K RaiNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah, USA.
David R EberhardtNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah, USA.
Anthony M BalynasNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah, USA.
Melissa J S MacEwenDepartment of Pharmacology, University of Washington, Seattle, Washington, USA.
Ashley R BrattNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah, USA.
Yasemin SancakDepartment of Pharmacology, University of Washington, Seattle, Washington, USA.
Dipayan ChaudhuriNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah, USA.ORCID 0000-0003-0605-7334

Funding

Metabolic Impact and Mechanism of Enhanced Mitochondrial Calcium Uptake in Mitochondrial CardiomyopathiesR01HL141353 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Dipayan Chaudhuri · 2018 to 2026
$4.3M
Regulation of the mitochondrial calcium uniporterR01HL165797 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Dipayan Chaudhuri · 2022 to 2026
$2.5M
Molecular Dissection of Mitochondria-Organelle InteractionsDP2ES032761 · NIEHS · UNIVERSITY OF WASHINGTON · PI SANCAK, YASEMIN S · 2020 to 2023
$2.4M
Investigating Calcium Homeostasis During a Key Mitochondrial Stress PathwayF31AG072716 · NIA · UNIVERSITY OF WASHINGTON · PI MACEWEN, MELISSA JANE · 2022 to 2023
$66k
NHLBI NIH HHS R01 HL141353NHLBI NIH HHS R01 HL165797NIA NIH HHS F31 AG072716NIEHS NIH HHS DP2 ES032761
6 · The paper itself

Abstract

Mitochondrial Ca

Indexed as

CalciumCalcium ChannelsMitochondriaAnimalsHEK293 CellsHumansMutationCalciumCalcium Channelsmitochondrial calcium uniportercalcium channelsEMREFörster resonance energy transferischemia‐reperfusion injuryMICU1mitochondrial calcium uniporter

Identifiers

PMID40227803
PMCPMC11996009

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.