Evidence map›Paper›PMID 40227600›Full record

ArticleCancers2025

Predictors for Emergency Admission Among Homeless Metastatic Cancer Patients and Association of Social Determinants of Health with Negative Health Outcomes.

Poolakkad S Satheeshkumar, Stephen T Sonis, Joel B Epstein, Roberto Pili

Abstract read
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Poolakkad S SatheeshkumarDepartment of Medicine, Division of Hematology and Oncology, University at Buffalo, Buffalo, NY 14203, USA.
Stephen T SonisDivisions of Oral Medicine, Brigham and Women's Hospital and the Dana-Faber Cancer Institute, Boston, MA 02115, USA.ORCID 0000-0001-6480-2625
Joel B EpsteinCity of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Roberto PiliDepartment of Medicine, Division of Hematology and Oncology, University at Buffalo, Buffalo, NY 14203, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesSocial determinants of health (SDOHs) are especially impactful with respect to emergency reliance among patients with cancer.

methodsTo better predict the extent to which SDOHs affect emergency admissions in homeless patients with metastatic disease, we employed machine learning models, Lasso, ridge, random forest (RF), and elastic net (EN) regression. We also examined prostate cancer (PC), breast cancer (BC), lung (LC) cancer, and cancers of the lip, oral cavity, and pharynx (CLOP) for association between key SDOH variables-homelessness and living alone-and clinical outcomes. For this, we utilized generalized linear models to assess the association while controlling for patient and clinical characteristics. We used the United States National Inpatient Sample database for this study.

resultsThere were 2635 (weighted) metastatic cancer patients with homelessness. Transfer from another facility or not, elective admission or not, deficiency anemia, alcohol dependence, weekend admission or not, and blood loss anemia were the important predictors of emergency admission. C-statistics were associated with Lasso (train AUC-0.85; test AUC-0.86), ridge (85, 88), RF (0.96, 0.85), and EN (0.83, 0.80), respectively. In the adjusted analysis, PC homelessness was significantly associated with anxiety and depression (5.15, 95% CI: 3.17-8.35) and a longer LOS (1.96; 95% CI: 1.03-3.74). Findings were comparable in the BC, LC, and CLOP cohorts. Cancer patients with poor SDOHs presented with the worst clinical outcomes.

conclusionsCancer patients with poor SDOH presented with worst clinical outcomes. The findings of this study highlight a vacuum in the cancer literature, and the recommendations stress the value of social support in achieving a better prognosis and Quality of life.

Indexed as

breast cancersburden of illnesscancers of the lip, oral cavity, and pharynxemergency admissionshomelessnesslung cancersopioid abuseproblems related to living aloneprostate cancerssocial determinants of health

Identifiers

PMID40227600
PMCPMC11987736

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.