ArticleCancers2025
Screening Mammography and Breast Cancer: Variation in Risk with Rare Deleterious or Predicted Deleterious Variants in DNA Repair Genes.
Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
45 authors.
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Abstract
backgroundWomen with a familial predisposition to breast cancer (BC) are offered screening at earlier ages and more frequently than women from the general population.
methodsWe evaluated the effect of screening mammography in 1552 BC cases with a hereditary predisposition to BC unexplained by
resultsOverall, having been exposed to mammograms (never vs. ever) was not associated with BC risk. However, an increase in BC risk of 4% (95% CI: 1-6%) per additional exposure was found under the assumption of linearity. When grouped according to D-PDV carrier status, mammograms doubled the BC risk of women carrying a D-PDV in Group "Reduced", as compared to those carrying a D-PDV in Group "Increased".
conclusionsOur study is the first to investigate the joint effect of mammogram exposure and variants in DNA repair genes other than
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