Evidence map›Paper›PMID 40227584›Full record

ReviewCancers2025

Management of Patients with IBD and History of Cancer.

Ilaria Faggiani, Sarah Bencardino, Mariangela Allocca, Federica Furfaro, Alessandra Zilli, Tommaso Lorenzo Parigi, Clelia Cicerone, Virginia Solitano, Laurent Peyrin-Biroulet, Silvio Danese and 1 more

Abstract readReview
In one paragraph

Review in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ilaria FaggianiDepartment of Gastroenterology and Endoscopy I, IRCCS San Raffaele Hospital and Vita-Salute San Raffaele University, 20132 Milan, Italy.
Sarah BencardinoDepartment of Gastroenterology and Endoscopy I, IRCCS San Raffaele Hospital and Vita-Salute San Raffaele University, 20132 Milan, Italy.ORCID 0000-0003-3844-3483
Mariangela AlloccaDepartment of Gastroenterology and Endoscopy I, IRCCS San Raffaele Hospital and Vita-Salute San Raffaele University, 20132 Milan, Italy.
Federica FurfaroDepartment of Gastroenterology and Endoscopy I, IRCCS San Raffaele Hospital and Vita-Salute San Raffaele University, 20132 Milan, Italy.
Alessandra ZilliDepartment of Gastroenterology and Endoscopy I, IRCCS San Raffaele Hospital and Vita-Salute San Raffaele University, 20132 Milan, Italy.
Tommaso Lorenzo ParigiDepartment of Gastroenterology and Endoscopy I, IRCCS San Raffaele Hospital and Vita-Salute San Raffaele University, 20132 Milan, Italy.
Clelia CiceroneDepartment of Gastroenterology and Endoscopy I, IRCCS San Raffaele Hospital and Vita-Salute San Raffaele University, 20132 Milan, Italy.ORCID 0009-0003-5400-2765
Virginia SolitanoDepartment of Gastroenterology and Endoscopy I, IRCCS San Raffaele Hospital and Vita-Salute San Raffaele University, 20132 Milan, Italy.
Laurent Peyrin-BirouletINSERM NGERE, Department of Gastroenterology, INFINY Institute, CHRU Nancy, F-54500 Vandœuvre-lès-Nancy, France.
Silvio DaneseDepartment of Gastroenterology and Endoscopy I, IRCCS San Raffaele Hospital and Vita-Salute San Raffaele University, 20132 Milan, Italy.ORCID 0000-0001-7341-1351
Ferdinando D'AmicoDepartment of Gastroenterology and Endoscopy I, IRCCS San Raffaele Hospital and Vita-Salute San Raffaele University, 20132 Milan, Italy.ORCID 0000-0002-8591-6995

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of advanced therapies, including biologics and small molecules, has become an established clinical practice for the treatment of moderate-to-severe ulcerative colitis (UC) and Crohn's disease (CD). However, certain patient populations, such as those with a history of cancer, are often excluded from clinical trials evaluating the efficacy and safety of these therapies. This exclusion has historically left clinicians with limited evidence to guide treatment decisions in this high-risk group. Nevertheless, emerging real-world data and updated guidelines increasingly support the safe use of advanced therapies in patients with a prior malignancy. Risk stratification and a multidisciplinary approach, including oncologist input, remain critical in optimizing patient outcomes by assessing both cancer recurrence risk and disease activity. This review aims to provide a comprehensive overview of the current evidence, address existing knowledge gaps, and offer practical insights for the management of IBD in patients with a history of cancer.

Indexed as

cancer historyCDCrohn’s diseaseIBDinflammatory bowel diseasemalignanciesUCulcerative colitis

Identifiers

PMID40227584
PMCPMC11988009

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.