Evidence map›Paper›PMID 40227493›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2025

Multiplex PCR for the Rapid Diagnosis of Myeloproliferative Neoplasms.

Laura Semenuk, Alissa Palazzolo, Kristen McCambridge, Henry Wong, Michael J Rauh, Harriet Feilotter, Graeme Quest

Abstract read
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Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Laura SemenukDepartment of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada. Laura.Semenuk@queensu.ca.
Alissa PalazzoloDepartment of Clinical Laboratory Services, Kingston Health Sciences Centre, Kingston, ON, Canada.
Kristen McCambridgeDepartment of Clinical Laboratory Services, Kingston Health Sciences Centre, Kingston, ON, Canada.
Henry WongDepartment of Clinical Laboratory Services, Kingston Health Sciences Centre, Kingston, ON, Canada.
Michael J RauhDepartment of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada.
Harriet FeilotterDepartment of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada.
Graeme QuestDepartment of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada. Graeme.Quest@kingstonhsc.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myeloproliferative neoplasms (MPN) develop as a disease of aging, due to the disruption of normal hematopoiesis, triggered by somatic mutations and a sustained inflammatory cycle. Driving variants within JAK2, MPL, and CALR are associated with various subtypes of MPN, with known targeted therapeutics and guided patient prognosis. Targeted clinical testing for the diagnosis of these precise driving variants within these key genes has an integral role for personalized medicine.

Indexed as

Multiplex Polymerase Chain ReactionMyeloproliferative DisordersCalreticulinHumansJanus Kinase 2MutationReceptors, ThrombopoietinCalreticulinCALR protein, humanJAK2 protein, humanJanus Kinase 2MPL protein, humanReceptors, ThrombopoietinAllele-specific PrimersCapillary ElectrophoresisHematopoietic Stem CellsMultiplex PCRMyeloproliferative NeoplasmPersonalized Medicine

Identifiers

PMID40227493

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.