Camellia nitidissima Chi extract ameliorates dextran sulfate sodium-induced acute ulcerative colitis in mice by inhibiting TLR4/NF-κB-mediated inflammatory activation.

Lirong Li, Rui Huang, Wenwen Li, Dengjie Yao, Beibei Zhang, Mengna Li, Shunan Luo, Yu Qin, Wenwen Zhang

Abstract read

In one paragraph

Article in Inflammopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Lirong LiFaculty of Food Science and Engineering, Kunming University of Science and Technology, Room 203, Agricultural Engineering Building, No. 727, Jingming South Road, Chenggong District, Kunming, 650500, Yunnan Province, China.

Rui HuangZhongken Huashan Mu Dairy Co., LTD, Weinan, 714000, Shaanxi Province, China.

Wenwen LiFaculty of Food Science and Engineering, Kunming University of Science and Technology, Room 203, Agricultural Engineering Building, No. 727, Jingming South Road, Chenggong District, Kunming, 650500, Yunnan Province, China.

Dengjie YaoFaculty of Food Science and Engineering, Kunming University of Science and Technology, Room 203, Agricultural Engineering Building, No. 727, Jingming South Road, Chenggong District, Kunming, 650500, Yunnan Province, China.

Beibei ZhangFaculty of Food Science and Engineering, Kunming University of Science and Technology, Room 203, Agricultural Engineering Building, No. 727, Jingming South Road, Chenggong District, Kunming, 650500, Yunnan Province, China.

Mengna LiFaculty of Food Science and Engineering, Kunming University of Science and Technology, Room 203, Agricultural Engineering Building, No. 727, Jingming South Road, Chenggong District, Kunming, 650500, Yunnan Province, China.

Shunan LuoFaculty of Food Science and Engineering, Kunming University of Science and Technology, Room 203, Agricultural Engineering Building, No. 727, Jingming South Road, Chenggong District, Kunming, 650500, Yunnan Province, China.

Yu QinFaculty of Food Science and Engineering, Kunming University of Science and Technology, Room 203, Agricultural Engineering Building, No. 727, Jingming South Road, Chenggong District, Kunming, 650500, Yunnan Province, China. 274435757@qq.com.ORCID http://orcid.org/0000-0003-3015-1451

Wenwen ZhangFaculty of Food Science and Engineering, Kunming University of Science and Technology, Room 203, Agricultural Engineering Building, No. 727, Jingming South Road, Chenggong District, Kunming, 650500, Yunnan Province, China. 2765974317@qq.com.

Funding

Department of Science and Technology of Shaanxi Province Department of City Linkage Weinan Modern Agricultural Key Projects Grant No. 2022GD-TSLD-58-1Special Project for High-level Scientific and Technological Talents and Innovation Teams of Yunnan Province Grant No. 202405AS350005Yunnan Fundamental Research Projects Grant NO. 202301AS070030Yunnan Province Talent Training Project Grant No. KKRD202023026

6 · The paper itself

Abstract

Camellia nitidissima Chi (CNC), whose main composition was gallic acid, catechin, procyanidin-gallate, apigenin-pentosyl-glucoside, vitexin, cyanidin-3-o-glucoside, myricitrin-glucoside, gallocatechin-gallate, epicatechin and rutin, posses sound anti-inflammatory and antioxidant effects. This study aimed to explore the protective effects and mechanisms of the alcoholic extract of CNC on dextran sulfate sodium-induced ulcerative colitis. CNC effectively maintained weight and colon length, and significantly ameliorated colonic histopathological damage. Furthermore, CNC mitigated colitis-induced oxidative stress and exhibited anti-inflammatory properties in UC mice by reducing levels of myeloperoxidase (MPO) and malondialdehyde (MDA), decreasing the production of nitric oxide (NO), prostaglandin E2 (PGE2), interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α). In addition, CNC downregulated the protein expression levels of TLR4, p-NF-κBP65, and p-IκBα of the inflammation-related TLR4/NF-κB signaling pathways. Validation of the molecular docking results also revealed that rutin, the most abundant compound in CNC, interacts with TLR4 and NF-κB protein mainly through hydrogen bonds. CNC also promoted the proliferation of Lactobacillus and Bifidobacterium while reducing the number of Enterococcus, E. coli, Bacteroides, and Peptococcus in mice to improve the intestinal environment and alleviate colitis. CNC inhibited TLR4/NF-κB signaling pathways to relieve inflammation and oxidative damage on UC, is a potential development of natural medicine for UC.

Indexed as

CamelliaColitis, UlcerativeNF-kappa BPlant ExtractsToll-Like Receptor 4AnimalsAnti-Inflammatory AgentsDextran SulfateDisease Models, AnimalInflammationMaleMiceMolecular Docking SimulationOxidative StressSignal TransductionAnti-Inflammatory AgentsDextran SulfateNF-kappa BPlant ExtractsTlr4 protein, mouseToll-Like Receptor 4Camellia nitidissima ChiInflammatoryNF-κBTLR4Ulcerative colitis

Identifiers

PMID40227476

DOI10.1007/s10787-025-01743-9

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.