ArticleAntioxidants (Basel, Switzerland)2025
Synergistic Neuroprotective and Immunomodulatory Effects of Cocoa Seed Husk and Guarana Extract: A Nutraceutical Approach for Parkinson's Disease Management.
Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Potential Relevance of Amazonian Diet Components in Parkinson's Disease: An Integrative Review with Multivariate Analysis.Nutrients · 2026Review
- Cocoa Bean Shell as a Functional Food By-Product: Antioxidant Potential and Toxicological Thresholds inFood science & nutrition · 2026Article
- Cocoa polyphenols in brain health: BDNF/CREB-mediated mechanisms in depression, cognition, and the gut-brain axis.Frontiers in nutrition · 2026Review
- Plants, Pills, and the Brain: Exploring Phytochemicals and Neurological Medicines.International journal of plant, animal and environmental sciences · 2025Article
Corrections and comments
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Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundParkinson's disease (PD) is a progressive neurodegenerative disorder linked to oxidative stress, mitochondrial dysfunction, and neuroinflammation. This study evaluates the neurofunctional and immunomodulatory effects of an aqueous extract combining cocoa seed husk and guarana powder (GuaCa). Eighteen extracts were characterized by flavonoid and polyphenol content, antioxidant activity, and genoprotective potential. The HCE3 extract, rich in catechins, quercetin, and epigallocatechin gallate, was selected for further analysis in three models:
resultsThe extracts showed antioxidant and genoprotective activity and contained flavonoid. No significant toxicity was observed in
conclusionGuaCa shows promise as a nutraceutical for managing neuroinflammation and mitochondrial dysfunction in PD. Further clinical studies are needed to confirm GuaCa extract efficacy and potential for neuroprotective dietary strategies.
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