ArticleEndocrine2025
Recovery of pituitary function in patients with apoplexy immediately after surgical resection of necrotic tumors.
Article in Endocrine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Correlation between intrasellar pressure, pituitary adenoma invasiveness, pituitary dysfunction, and apoplexy.Frontiers in endocrinology · 2025Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPituitary tumor apoplexy [PTA] and Rathke's Cleft Cyst apoplexy (RCCA) are uncommon disorders causing hypopituitarism.
objectiveExamine the value of perioperative hormonal alterations in predicting recovery of impaired function in patients with PTA and RCCA.
methodsConsecutive PTA (N = 97) and RCCA (N = 41) patients who had emergent surgery received dexamethasone until surgery. Perioperative HPA function and prolactin levels were frequently assessed while hydrocortisone therapy was provided to those exhibiting clinical or biochemical evidence [cortisol <10 ug/dL; <276 nmol/L] for insufficiency. Patients with multiple perioperative cortisol levels ≥15 ug/dL [414 nmol/L] were considered to have normal postoperative HPA function.
resultsPatients with PTA were more likely to be males, older, have more severe hormonal deficits and worse visual impairment than those with RCCA. Impaired HPA function and lower prolactin levels were more prevalent in patients with PTA than in those with RCCA. Perioperative recovery of HPA function was demonstrated by a brisk increase in ACTH followed by a rise in two ACTH-dependent adrenal steroids: cortisol and DHEA-S in 23/59 [39%] patients with PTA and in 16/20 [80%] others with RCCA. The perioperative rise in ACTH was mirrored by a decline in prolactin levels. Patients recovering function had higher [P < 0.01] preoperative prolactin levels than those with persistent deficit. Follow up HPA testing confirmed perioperative assessment.
conclusionsPerioperative measurements of ACTH and its dependent adrenal steroid levels accurately predict recovery of HPA function and support previously postulated role of increased intrasellar pressure and stalk compression in the pathogenesis of hypopituitarism in this setting.
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