Evidence map›Paper›PMID 40227454›Full record

ArticleAntioxidants (Basel, Switzerland)2025

Myrobalan Fruit Extracts Modulate Immunobiochemical Pathways In Vitro.

Stefanie Hofer, Marcel Jenny, Angela Klein, Kathrin Becker, Lucia Parráková, Florian Überall, Markus Ganzera, Dietmar Fuchs, Hubert Hackl, Pablo Monfort-Lanzas and 1 more

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Stefanie HoferInstitute of Medical Biochemistry, Medical University of Innsbruck, Biocenter, 6020 Innsbruck, Austria.
Marcel JennyInstitute of Medical Biochemistry, Medical University of Innsbruck, Biocenter, 6020 Innsbruck, Austria.
Angela KleinInstitute of Medical Biochemistry, Medical University of Innsbruck, Biocenter, 6020 Innsbruck, Austria.
Kathrin BeckerInstitute of Medical Biochemistry, Medical University of Innsbruck, Biocenter, 6020 Innsbruck, Austria.
Lucia ParrákováInstitute of Medical Biochemistry, Medical University of Innsbruck, Biocenter, 6020 Innsbruck, Austria.
Florian ÜberallInstitute of Medical Biochemistry, Medical University of Innsbruck, Biocenter, 6020 Innsbruck, Austria.
Markus GanzeraInstitute of Pharmacy, Pharmacognosy, Center for Molecular Biosciences (CMBI), University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-7407-9060
Dietmar FuchsInstitute of Biological Chemistry, Medical University of Innsbruck, Biocenter, 6020 Innsbruck, Austria.ORCID 0000-0003-1627-9563
Hubert HacklInstitute of Bioinformatics, Medical University of Innsbruck, Biocenter, 6020 Innsbruck, Austria.ORCID 0000-0003-4055-3841
Pablo Monfort-LanzasInstitute of Medical Biochemistry, Medical University of Innsbruck, Biocenter, 6020 Innsbruck, Austria.ORCID 0000-0003-2589-3960
Johanna M GostnerInstitute of Medical Biochemistry, Medical University of Innsbruck, Biocenter, 6020 Innsbruck, Austria.ORCID 0000-0003-1532-5177

Funding

Austrian Research Promotion Agency 818111
6 · The paper itself

Abstract

Myrobalan fruits are important ingredients of traditional remedies, such as the Ayurvedic formulation Triphala or the Tibetan formulation Bras bu 3. Myrobalan-containing remedies are described to have positive effects on metabolism, the cardiovascular system, and the immune system. The chemical composition of botanical mixtures can be very complex, and it is often impossible to identify individual compounds as specific active ingredients, which suggests a multi-target mode of action. In this in vitro study, the effect of myrobalan extracts in human cell models was investigated to gain more information about the molecular mechanism of action and to find possible synergistic effects. Direct and indirect antioxidant effects were investigated, and the activation of immunobiochemical metabolic pathways involved in the cellular immune response was examined in cell lines treated with extracts of the fruits of

Indexed as

antioxidantscell modelsgene expression analysisimmunobiochemistryinflammationmyrobalan fruits

Identifiers

PMID40227454
PMCPMC11939258

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.