Evidence map›Paper›PMID 40227422›Full record

ArticleAntioxidants (Basel, Switzerland)2025

HSA Adductomics in the Shanghai Women's Health Study Links Lung Cancer in Never-Smokers with Air Pollution, Redox Biology, and One-Carbon Metabolism.

Partow Imani, Hasmik Grigoryan, Sandrine Dudoit, Xiao-Ou Shu, Jason Wong, Luoping Zhang, Junfeng Zhang, Wei Hu, Qiuyin Cai, Yutang Gao and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Use of Human Serum Albumin CysAntioxidants (Basel, Switzerland) · 2026
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Partow ImaniSchool of Public Health, University of California, Berkeley, Berkeley, CA 94720, USA.
Hasmik GrigoryanSchool of Public Health, University of California, Berkeley, Berkeley, CA 94720, USA.
Sandrine DudoitDepartment of Statistics, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-6069-8629
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.ORCID 0000-0002-0711-8314
Jason WongEpidemiology and Community Health Branch, National Heart Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA.
Luoping ZhangSchool of Public Health, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0001-7866-8391
Junfeng ZhangGlobal Health Research Center, Duke Kunshan University, Kunshan 215316, China.ORCID 0000-0003-3759-6672
Wei HuDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA.
Qiuyin CaiDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.ORCID 0000-0002-9384-5648
Yutang GaoDepartment of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
Batel BlechterDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA.
Mohammad RahmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Nathaniel RothmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA.
Qing LanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA.
Stephen M RappaportSchool of Public Health, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-3806-0848

Funding

Training CoreP42ES004705 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI MCHALE, CLIONA · 1987 to 2025
$74.6M
Using Adductomics to Characterize Exposures to CarcinogensR33CA191159 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI RAPPAPORT, STEPHEN MORRIS · 2015 to 2017
$1.1M
National Institute for Environmental Health Sciences P42ES004705NCI NIH HHS R33CA191159NIEHS NIH HHS P42 ES004705
6 · The paper itself

Abstract

Nearly one fourth of lung cancers occur among never-smokers and are predominately lung adenocarcinomas (LUADs) that are distinct from smoking-related cancers. Causal links between LUADs in never-smokers have been attributed to reactive oxygen species (ROS) arising from airborne fine particulate matter (PM

Indexed as

cysteine 34 (Cys34)fine particulate matter (PM2.5)human serum albumin (HSA) adductslung cancerlysine 525 (Lys525)never-smokerspolycyclic aromatic hydrocarbons (PAHs)reactive oxygen species (ROS)

Identifiers

PMID40227422
PMCPMC11939640

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.