Evidence map›Paper›PMID 40227278›Full record

ArticleAntioxidants (Basel, Switzerland)2025

Impact of Hospitalization on Sarcopenia, NADPH-Oxidase 2, Oxidative Stress, and Low-Grade Endotoxemia in Elderly Patients.

Chiara Bagnato, Arianna Magna, Elena Mereu, Sciaila Bernardini, Simona Bartimoccia, Roberta Marti, Pietro Enea Lazzerini, Alessandra D'Amico, Evaristo Ettorre, Giovambattista Desideri and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Chiara BagnatoDepartment of Clinical Internal, Anaesthesiologic and Cardiovascular Science, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, Italy.
Arianna MagnaDepartment of Clinical Internal, Anaesthesiologic and Cardiovascular Science, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, Italy.
Elena MereuDepartment of Clinical Internal, Anaesthesiologic and Cardiovascular Science, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, Italy.ORCID 0009-0003-0198-7062
Sciaila BernardiniDepartment of Medical Sciences, Surgery and Neurosciences, University of Siena, 53100 Siena, Italy.
Simona BartimocciaDepartment of Clinical Internal, Anaesthesiologic and Cardiovascular Science, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, Italy.
Roberta MartiDepartment of Clinical Internal, Anaesthesiologic and Cardiovascular Science, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, Italy.
Pietro Enea LazzeriniDepartment of Medical Sciences, Surgery and Neurosciences, University of Siena, 53100 Siena, Italy.ORCID 0000-0001-6721-1214
Alessandra D'AmicoDepartment of Medical and Surgical Sciences and Biotechnologies, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-5571-4583
Evaristo EttorreDepartment of Clinical Internal, Anaesthesiologic and Cardiovascular Science, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, Italy.
Giovambattista DesideriDepartment of Clinical Internal, Anaesthesiologic and Cardiovascular Science, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, Italy.
Pasquale PignatelliDepartment of Clinical Internal, Anaesthesiologic and Cardiovascular Science, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, Italy.ORCID 0000-0002-2265-7455
Francesco VioliSapienza University of Rome, 00185 Rome, Italy.
Roberto CarnevaleIRCCS Neuromed, 86077 Pozzilli, Italy.ORCID 0000-0002-6216-9595
Lorenzo LoffredoDepartment of Clinical Internal, Anaesthesiologic and Cardiovascular Science, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, Italy.ORCID 0000-0002-6542-6235
Neurodegenerative Study GroupDepartment of Clinical Internal, Anaesthesiologic and Cardiovascular Science, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHospitalization in older adults often worsens sarcopenia due to prolonged bed rest, poor nutrition, and inactivity. This study examined how hospitalization impacts muscle mass, focusing on oxidative stress and gut-derived endotoxemia.

methodsThirty-one hospitalized older adults were compared with 31 outpatients. Ultrasound was used to measure the thickness of the rectus femoris (RF), intercostal, and diaphragmatic muscles at admission and discharge. Serum levels of LPS, zonulin, sNOX2-dp, and H

resultsHospitalized patients had higher serum levels of sNOX2-dp, H

conclusionsHospitalization in older adult patients elevates NOX2 blood levels, correlating with reduced muscle mass. Increased low-grade endotoxemia may trigger NOX2 activation, generating oxidative stress that accelerates muscle degeneration and can lead to sarcopenia.

Indexed as

aginghospitalizationmuscle ultrasoundNADPH oxidaseNOX2oxidative stressphysical activitysarcopenia

Identifiers

PMID40227278
PMCPMC11939531

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.