Evidence map›Paper›PMID 40227270›Full record

ReviewAntioxidants (Basel, Switzerland)2025

Oxidative Stress in Brain Function.

Daniela-Marilena Trofin, Dragos-Petrica Sardaru, Dan Trofin, Ilie Onu, Andrei Tutu, Ana Onu, Cristiana Onită, Anca Irina Galaction, Daniela Viorelia Matei

Registry-linked trialAbstract readReview
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07591935 (Artificial Intelligence and Mindfulness Meditation), which is not on this map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07591935 nacompletednot on this map

Artificial Intelligence and Mindfulness Meditation: Innovative Methods to Reduce Stress Amongst Medical School Students

TypeinterventionalSponsorSaint James School of MedicineRan2024 to 2024Enrolled20ConditionsStressArmsMindfulness-Based Stress Reduction Course, Apollo Neuro Wearable
3 · Its place in the literature

Who cites it

51 citing papers in PubMed.

  1. Review
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  16. Neuroprotective properties ofIBRO neuroscience reports · 2026
    Article
  17. Article
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  19. Review
  20. Neuroprotective Effects ofPharmaceuticals (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Daniela-Marilena TrofinDoctoral School, University of Medicine and Pharmacy "Grigore T. Popa", 700454 Iasi, Romania.
Dragos-Petrica SardaruDepartment of Biomedical Sciences, Faculty of Medical Bioengineering, University of Medicine and Pharmacy "Grigore T. Popa", 700454 Iasi, Romania.
Dan TrofinDepartment of Biomedical Sciences, Faculty of Medical Bioengineering, University of Medicine and Pharmacy "Grigore T. Popa", 700454 Iasi, Romania.ORCID 0000-0002-1480-3467
Ilie OnuDepartment of Biomedical Sciences, Faculty of Medical Bioengineering, University of Medicine and Pharmacy "Grigore T. Popa", 700454 Iasi, Romania.ORCID 0000-0002-1003-0719
Andrei TutuDoctoral School, University of Medicine and Pharmacy "Grigore T. Popa", 700454 Iasi, Romania.
Ana OnuDoctoral School, University of Medicine and Pharmacy "Grigore T. Popa", 700454 Iasi, Romania.ORCID 0009-0000-2051-4728
Cristiana OnităDepartment of Biomedical Sciences, Faculty of Medical Bioengineering, University of Medicine and Pharmacy "Grigore T. Popa", 700454 Iasi, Romania.
Anca Irina GalactionDepartment of Biomedical Sciences, Faculty of Medical Bioengineering, University of Medicine and Pharmacy "Grigore T. Popa", 700454 Iasi, Romania.ORCID 0000-0003-2365-6670
Daniela Viorelia MateiDepartment of Biomedical Sciences, Faculty of Medical Bioengineering, University of Medicine and Pharmacy "Grigore T. Popa", 700454 Iasi, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative stress (OS) is an important factor in the pathophysiology of numerous neurodegenerative disorders, such as Parkinson's disease, multiple sclerosis, cerebrovascular pathology or Alzheimer's disease. OS also significantly influences progression among the various neurodegenerative disorders. The imbalance between the formation of reactive oxygen species (ROS) and the body's capacity to neutralize these toxic byproducts renders the brain susceptible to oxidative injury. Increased amounts of ROS can result in cellular malfunction, apoptosis and neurodegeneration. They also represent a substantial factor in mitochondrial dysfunction, a defining characteristic of neurodegenerative disorders. Comprehending the fundamental mechanisms of OS and its interactions with mitochondrial function, neuroinflammation and cellular protective pathways becomes essential for formulating targeted therapeutics to maintain brain health and reduce the impacts of neurodegeneration. We address recent highlights on the role of OS in brain function in terms of significance for neuronal health and the progression of neurodegenerative disorders.

Indexed as

Alzheimer diseasebrain functionmultiple sclerosisoxidative stressParkinson diseasephysical exercisestroke

Identifiers

PMID40227270
PMCPMC11939459

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.