Evidence map›Paper›PMID 40227269›Full record

ArticleAntioxidants (Basel, Switzerland)2025

A Fluorescent Probe for Imaging and Treating S-Nitrosation Stress in OGD/R Cells.

Hui Ye, Chen Zhang, Lerong Li, Cunrui Li, Jiayue Yu, Duorui Ji, Zhuangzhuang Liang, Jianbing Wu, Zhangjian Huang

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hui YeState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China.ORCID 0000-0002-1771-7732
Chen ZhangState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China.ORCID 0009-0005-6708-9833
Lerong LiState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China.
Cunrui LiState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China.ORCID 0009-0003-5523-7478
Jiayue YuState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China.
Duorui JiState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China.
Zhuangzhuang LiangState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China.
Jianbing WuState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China.
Zhangjian HuangState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China.

Funding

"Double First-Class" University projects CPU2022PZQ15 from China Pharmaceutical UniversityFundamental Research Funds for the Central Universities Grant No. 2632023TD04National Natural Science Foundation of China 82473773, 82173681, 82104004 and 82273780Natural Science Foundation of Xinjiang Uygur Autonomous Region 2022D01D38 and 2023D01D16open project of the State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia Fund SKL-HIDCA-2024-4
6 · The paper itself

Abstract

Protein S-nitrosation, a redox post-translational modification elicited by nitric oxide (NO), is essential for modulating diverse protein functions and signaling pathways. Dysregulation of S-nitrosation is implicated in various pathological processes, including oxygen-glucose deprivation/reperfusion (OGD/R) injury, a widely used model for ischemia-reperfusion diseases. The dynamic changes in S-nitrosothiols (SNOs) during ischemia-reperfusion highlight the need for theranostic strategies to monitor and modulate SNO levels based on pathological progression. However, to date, no theranostic strategies have been reported for addressing dysregulated SNO in disease models, particularly in OGD/R conditions. Here, we report the development of a selective probe

Indexed as

imagingnitric oxideOGD/RS-nitrosationS-nitrosylationtheranostictreatment

Identifiers

PMID40227269
PMCPMC11939710

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.