Evidence map›Paper›PMID 40227232›Full record

ArticleeLife2025

Enteric glia regulate Paneth cell secretion and intestinal microbial ecology.

Aleksandra Prochera, Anoohya N Muppirala, Gavin A Kuziel, Salima Soualhi, Amy Shepherd, Liang Sun, Biju Issac, Harry J Rosenberg, Farah Karim, Kristina Perez and 5 more

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Macrophage-glia interactions regulate immune damage to enteric neurons during West Nile virus infection.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Chronic Heat Stress Can Induce Conjugation of a NovelAntibiotics (Basel, Switzerland) · 2025
    Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Aleksandra Prochera *Division of Gastroenterology, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, United States.ORCID https://orcid.org/0009-0006-5203-9507
Anoohya N Muppirala *Division of Gastroenterology, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, United States.ORCID https://orcid.org/0000-0002-6810-4127
Gavin A Kuziel *Division of Gastroenterology, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, United States.
Salima Soualhi *Division of Gastroenterology, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, United States.
Amy Shepherd *Division of Gastroenterology, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, United States.
Liang SunResearch Computing, Department of Information Technology, Boston Children's Hospital, Boston, United States.
Biju IssacResearch Computing, Department of Information Technology, Boston Children's Hospital, Boston, United States.ORCID https://orcid.org/0000-0002-7311-678X
Harry J RosenbergDivision of Gastroenterology, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, United States.
Farah KarimInstitute of Human Nutrition, Columbia University Irving Medical Center, New York, United States.
Kristina PerezDivision of Gastroenterology, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, United States.
Kyle H SmithDepartment of Surgery, Beth Israel Deaconess Medical Center, Boston, United States.
Tonora H ArchibaldResearch Computing, Department of Information Technology, Boston Children's Hospital, Boston, United States.
Seth Rakoff-NahoumDivision of Gastroenterology, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, United States.
Susan J HagenDepartment of Surgery, Beth Israel Deaconess Medical Center, Boston, United States.
Meenakshi RaoDivision of Gastroenterology, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, United States.ORCID https://orcid.org/0000-0002-8194-9204

Funding

STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WAYNE I LENCER · 1986 to 2026
$32.4M
Immunological and Microbial Mechanisms in Food AllergyR01AI126915 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI Talal Amine Chatila, Seth Rakoff-Nahoum · 2017 to 2026
$4.9M
Programmable benchtop bioreactors for scalable eco-evolutionary dynamics of the human microbiomeR01AI171100 · NIAID · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI KHALIL, AHMAD SAMIR, RAKOFF-NAHOUM, SETH · 2022 to 2025
$4.1M
Targeting microbial dysbiosis in Food Allergy to restore toleranceR01AI158814 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI CHATILA, TALAL AMINE, RAKOFF-NAHOUM, SETH · 2021 to 2025
$3.0M
Microbial reactivation of sex steroids and visceral painR01DK130836 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI Meenakshi Rao · 2022 to 2026
$2.7M
Positive Selection as a Host Mechanism to Control the MicrobiomeDP2GM136652 · NIGMS · BOSTON CHILDREN'S HOSPITAL · PI RAKOFF-NAHOUM, SETH · 2019 to 2019
$2.7M
Isoform- and Sex-Specific Functions of CGRP in Gastrointestinal MotilityR01DK135707 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI Meenakshi Rao · 2023 to 2026
$2.6M
Enteric Glia, Sexual Dimorphism and GI MotilityK08DK110532 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI RAO, MEENAKSHI · 2016 to 2021
$862k
National Defense Science and Engineering Graduate FellowshipNational Science Foundation Graduate Research Fellowship ProgramNIAID NIH HHS R01 AI126915NIAID NIH HHS R01 AI158814NIAID NIH HHS R01 AI171100NIDDK NIH HHS K08 DK110532NIDDK NIH HHS P30 DK034854NIDDK NIH HHS R01 DK130836NIDDK NIH HHS R01 DK135707NIGMS NIH HHS DP2 GM136652NIH HHS K08DK110532NIH HHS R01DK130836NIH HHS R01DK135707Schmidt Family Foundation FellowshipSmith Family Foundation Odyssey Award
6 · The paper itself

Abstract

Glial cells of the enteric nervous system (ENS) interact closely with the intestinal epithelium and secrete signals that influence epithelial cell proliferation and barrier formation in vitro. Whether these interactions are important in vivo, however, is unclear because previous studies reached conflicting conclusions (Prochera and Rao, 2023). To better define the roles of enteric glia in steady state regulation of the intestinal epithelium, we characterized the glia in closest proximity to epithelial cells and found that the majority express the gene Proteolipid protein 1 (

Indexed as

Enteric Nervous SystemGastrointestinal MicrobiomeIntestinal MucosaNeurogliaPaneth CellsAnimalsFemaleHumansMaleMiceMice, Inbred C57BLMyelin Proteolipid ProteinMyelin Proteolipid ProteinPlp1 protein, mouseantimicrobial peptidesenteric nervous systemglial cellinfectious diseasemicrobiologymouseneurosciencePaneth cells

Identifiers

PMID40227232
PMCPMC11996175

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.