ArticleAntioxidants (Basel, Switzerland)2025
Six-Day Fasting Causes Temporary Increases in Both Antioxidant Capacity and Oxidative Stress in Healthy Young Men: A Randomized Controlled Trial.
Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- The effect of 6-day fasting on physical performance and neuromuscular control in healthy men.Scientific reports · 2026Trial
- Article
- Metabolic stress and muscle mechanics: Acute response of isolated soleus and EDL muscles to prolonged fasting in mice with distinct muscle phenotypes.Biology open · 2025Article
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Authors and funding
4 authors.
Funding
Abstract
The impact of prolonged fasting on human oxidative stress (OS) levels and antioxidant defence mechanisms remains poorly understood. The aim of this current study was to investigate the redox response to a 6-day fast in a cohort of healthy men. Twenty-six participants were randomly allocated to a 6-day complete fasting or a control trial. Sympathetic activity, substrate oxidation, redox status, blood glucose, ketones, and testosterone concentrations were assessed. Throughout the fasting period, ketone concentration and fat oxidation increased, and carbohydrate oxidation and glucose and testosterone concentrations decreased. Heart rate increased on fasting days 2 and 4 and returned to the pre-fasting level on fasting day 6. Malondialdehyde (MDA) concentration increased after fasting days 4 and 6, and this increase was accompanied by an increase in the total antioxidant capacity (TAC), but the TAC/MDA ratio remained constant. Notably, all fasting-evoked changes returned to the baseline values after resumption of the regular diet. Thus, prolonged fasting activated both antioxidant defence and OS, but the redox balance was maintained. Consistent with this response, ketone concentration and sympathetic nervous system activity increased, and testosterone concentration decreased. These variables returned to the pre-fasting state after resumption of the usual eating habits.
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