Evidence map›Paper›PMID 40227214›Full record

ArticleAntioxidants (Basel, Switzerland)2025

Enhancing Photoprotection and Mitigating Ex Vivo Stratum Corneum Oxidative Stress: A Multifunctional Strategy Combining Rosmarinic Acid with UVB Filters.

Pedro Ivo de Souza Macedo, Claudinéia Aparecida Sales de Oliveira Pinto, Camila Faustino Hiraishi, Gabriela de Argollo Marques, Cassiano Carlos Escudeiro, Fabiana Vieira Lima Solino Pessoa, João Gregório, Catarina Rosado, Maria Valéria Robles Velasco, André Rolim Baby

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Evaluation ofMolecules (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Pedro Ivo de Souza MacedoDepartment of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.
Claudinéia Aparecida Sales de Oliveira PintoDepartment of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.ORCID 0000-0002-0066-1840
Camila Faustino HiraishiDepartment of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.
Gabriela de Argollo MarquesDepartment of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.
Cassiano Carlos EscudeiroIPclin, Integrated Research, Jundiaí 13201-013, Brazil.
Fabiana Vieira Lima Solino PessoaDepartment of Health Sciences, Faculty of Pharmacy, Federal University of Espírito Santo, São Mateus 29932-540, Brazil.ORCID 0000-0002-3563-4105
João GregórioCBIOS, Universidade Lusófona's Research Center for Biosciences & Health Technologies, 1749-024 Lisbon, Portugal.ORCID 0000-0002-6130-9453
Catarina RosadoCBIOS, Universidade Lusófona's Research Center for Biosciences & Health Technologies, 1749-024 Lisbon, Portugal.ORCID 0000-0002-6429-6213
Maria Valéria Robles VelascoDepartment of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.ORCID 0000-0003-4950-8510
André Rolim BabyDepartment of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.ORCID 0000-0001-9197-3024

Funding

CAPES 001CNPq 303862/2022-0Fapesp 2021/13276-0, and 2024/01920-0FCT DOI 10.54499/UIDP/04567/2020, DOI 10.54499/UIDB/04567/2020 and DOI 10.54499/EXPL/BTM-MAT/0112/2021
6 · The paper itself

Abstract

Exposure to ultraviolet (UV) radiation is a major contributor to skin injury, including sunburn, photoaging, and augmented risk of skin cancer, primarily through the generation of reactive oxygen species (ROS) that induce oxidative stress. Rosmarinic acid (RA), a natural phenolic compound with antioxidant and several other biological properties, has shown promise in mitigating such damage when incorporated into sunscreens. We evaluated RA's possible interactions and potential to enhance the efficacy of three worldwide known UVB filters-ethylhexyl methoxycinnamate (EHMC), octocrylene (OCT), and ethylhexyl salicylate (EHS). The performance of sunscreens with and without RA (0.1%

Indexed as

ethylhexyl methoxycinnamateethylhexyl salicylateoctocrylenesun protection factortape stripping

Identifiers

PMID40227214
PMCPMC11939370

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.