Evidence map›Paper›PMID 40227134›Full record

Trial reportJournal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG2025

Combination of LED illumination and daylight photodynamic therapy for the treatment of actinic keratosis in solid organ transplant recipients: a prospective, randomized, comparative, intra-patient study.

Inés Oteiza-Rius, Ana Morelló-Vicente, Leyre Aguado-Gil, Elisa María Gómez-González, Deiane Marcos-Muñagorri, Ane Carrera-Gabilondo, Rafael Salido-Vallejo

Abstract readRandomized Controlled TrialComparative Study
In one paragraph

Trial report in Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Inés Oteiza-RiusDepartment of Dermatology, University Clinic of Navarra, Pamplona, Spain.
Ana Morelló-VicenteDepartment of Dermatology, University Clinic of Navarra, Pamplona, Spain.ORCID 0000-0001-9342-9698
Leyre Aguado-GilDepartment of Dermatology, University Clinic of Navarra, Pamplona, Spain.
Elisa María Gómez-GonzálezDepartment of Dermatology, University Clinic of Navarra, Pamplona, Spain.
Deiane Marcos-MuñagorriDepartment of Dermatology, University Clinic of Navarra, Pamplona, Spain.
Ane Carrera-GabilondoDepartment of Dermatology, University Clinic of Navarra, Pamplona, Spain.
Rafael Salido-VallejoDepartment of Dermatology, University Clinic of Navarra, Pamplona, Spain.ORCID 0000-0001-7210-8959

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesSolid organ transplant recipients have an increased risk of developing actinic keratosis. Recent studies show greater effectiveness when combining daylight photodynamic therapy with a posterior LED illumination for their treatment in immunocompetent patients. The aim of this study was to compare the effectiveness of combining daylight photodynamic therapy and LED illumination versus daylight photodynamic therapy alone for the treatment of actinic keratosis in solid organ transplant recipients. PATIENTS AND

methodsThis randomized intra-patient study was conducted at University of Navarra Clinic. Solid organ transplant recipients with two 25 cm

resultsThirteen patients with a total of 169 AKs were recruited. At 12 weeks post-treatment, the area treated with daylight and conventional photodynamic therapy showed a greater reduction in actinic keratoses (79.55% vs. 65.43%, p < 0.05).

conclusionsOur results suggest greater effectiveness of combining daylight photodynamic therapy with LED illumination compared to daylight photodynamic therapy alone for the treatment of actinic keratosis in solid organ transplant recipients.

Indexed as

Keratosis, ActinicOrgan TransplantationPhotochemotherapyAdultAgedAminolevulinic AcidCombined Modality TherapyFemaleHumansMaleMiddle AgedPhotosensitizing AgentsProspective StudiesTransplant RecipientsTreatment OutcomeAminolevulinic AcidPhotosensitizing Agentsactinic keratosisPhotodynamic therapysolid organ transplant recipients

Identifiers

PMID40227134
PMCPMC12152521

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.