Evidence map›Paper›PMID 40227072›Full record

ArticleAntimicrobial agents and chemotherapy2025

PKPD modeling of the inoculum effect of combined ceftazidime/avibactam and colistin against KPC-3

Romain Aubry, Julien M Buyck, Alexia Chauzy, Laure Prouvensier, Jean-Winoc Decousser, Patrice Nordmann, Sebastian G Wicha, Sandrine Marchand, Nicolas Grégoire

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Romain AubryINSERM U1070 PHAR2, Université de Poitiers, Poitiers, Nouvelle-Aquitaine, France.ORCID 0009-0005-4482-9667
Julien M BuyckINSERM U1070 PHAR2, Université de Poitiers, Poitiers, Nouvelle-Aquitaine, France.ORCID 0000-0003-0299-4654
Alexia ChauzyINSERM U1070 PHAR2, Université de Poitiers, Poitiers, Nouvelle-Aquitaine, France.ORCID 0000-0001-6443-5888
Laure ProuvensierINSERM U1070 PHAR2, Université de Poitiers, Poitiers, Nouvelle-Aquitaine, France.
Jean-Winoc DecousserDepartment of Bacteriology and Infection Control, University Hospital Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil, France.ORCID 0000-0001-7105-6202
Patrice NordmannMedical and Molecular Microbiology, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.ORCID 0000-0002-1343-1622
Sebastian G WichaDepartment of Clinical Pharmacy, Institute of Pharmacy, University of Hamburg, Hamburg, Germany.
Sandrine MarchandINSERM U1070 PHAR2, Université de Poitiers, Poitiers, Nouvelle-Aquitaine, France.ORCID 0000-0001-5279-6678
Nicolas GrégoireINSERM U1070 PHAR2, Université de Poitiers, Poitiers, Nouvelle-Aquitaine, France.ORCID 0000-0001-6436-3757

Funding

Agence Nationale de la Recherche ANR-19-AMRB-0003-01
6 · The paper itself

Abstract

The inoculum effect (IE) characterizes a decrease in the antimicrobial effect of antibiotics with increasing inoculum. To face antimicrobial resistance, antibiotic combinations are progressively used. In this context, the effect of combination may be affected by IE, especially drugs for which an IE has been described. The objective was to characterize the IE of a carbapenemase (KPC-3)

Indexed as

Anti-Bacterial AgentsAzabicyclo Compoundsbeta-LactamasesCeftazidimeColistinKlebsiella pneumoniaeBacterial ProteinsDrug CombinationsKlebsiella InfectionsMicrobial Sensitivity TestsAnti-Bacterial Agentsavibactam, ceftazidime drug combinationAzabicyclo CompoundsBacterial Proteinsbeta-lactamase KPC-3, Klebsiella pneumoniaebeta-LactamasescarbapenemaseCeftazidimeColistinDrug Combinationsantimicrobial combinationceftazidime/avibactamcolistininoculum effectPKPD modeling

Identifiers

PMID40227072
PMCPMC12057351

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.