Evidence map›Paper›PMID 40227055›Full record

ArticlemSphere2025

Functional implications of respiratory syncytial virus F sequence variability: a comparative analysis using contemporary RSV isolates.

Kim Stobbelaar, Lotte Jacobs, Francisco I Serrano-Cano, Axelle Fransen, Winke Van der Gucht, Annemieke Smet, Benedicte Y De Winter, Paul Cos, Winnok de Vos, Kim Van Hoorenbeeck and 2 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kim StobbelaarLaboratory of Microbiology, Parasitology and Hygiene, Faculty of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.ORCID 0000-0002-3477-1159
Lotte JacobsLaboratory of Microbiology, Parasitology and Hygiene, Faculty of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Francisco I Serrano-CanoLaboratory of Microbiology, Parasitology and Hygiene, Faculty of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Axelle FransenLaboratory of Microbiology, Parasitology and Hygiene, Faculty of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Winke Van der GuchtLaboratory of Microbiology, Parasitology and Hygiene, Faculty of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Annemieke SmetLaboratory of Experimental Medicine and Pediatrics, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.ORCID 0000-0002-1271-6191
Benedicte Y De WinterLaboratory of Experimental Medicine and Pediatrics, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Paul CosLaboratory of Microbiology, Parasitology and Hygiene, Faculty of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.ORCID 0000-0003-4361-8911
Winnok de VosLaboratory of Cell Biology and Histology, Department of Veterinary Sciences, University of Antwerp, Antwerp, Belgium.ORCID 0000-0003-0960-6781
Kim Van HoorenbeeckLaboratory of Experimental Medicine and Pediatrics, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Stijn Verhulst *Laboratory of Experimental Medicine and Pediatrics, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Peter L Delputte *Laboratory of Microbiology, Parasitology and Hygiene, Faculty of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.ORCID 0000-0003-3972-616X

Funding

Bijzonder onderzoeksfonds UAntwerpen (BOF DOCPRO) 46824Flemish plan for Recovery and Resilience 48493Fonds Wetenschappelijk Onderzoek 1104922NFonds Wetenschappelijk Onderzoek 1S45125N
6 · The paper itself

Abstract

Respiratory syncytial virus (RSV) remains a major global health issue. Therapeutic options are limited, but new prophylactics, all targeting the fusion (F) glycoprotein, were recently licensed. Although F sequence variation is limited, it is unclear if and how this variability translates to phenotypical differences. We analyzed full F sequences of 105 contemporary RSV isolates, gathered from children presenting with acute lower respiratory tract infections. Based on F antigenic site variation, 20 isolates were selected for functional characterization. Although RSV F diversity is generally low, the overall mean pairwise distance between RSV-A strains is higher than RSV-B (0.014 vs 0.008,

Indexed as

Genetic VariationRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsViral Fusion ProteinsAntibodies, MonoclonalAntibodies, ViralChild, PreschoolGiant CellsHumansInfantPhylogenyAntibodies, MonoclonalAntibodies, ViralF protein, human respiratory syncytial virusViral Fusion Proteinsclinical isolatesfusion proteinrespiratory syncytial virus

Identifiers

PMID40227055
PMCPMC12108066

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.