Evidence map›Paper›PMID 40227049›Full record

ArticlemSphere2025

Characterizing antimicrobial activity of environmental

Audrey Cowen, Bonnie Yiu, Sara Fallah, Kirsten J Meyer, Emily Puumala, Yunjin Lee, Haley L Zubyk, Nicole Robbins, Justin R Nodwell, Jessie MacAlpine and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Audrey Cowen *Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Bonnie Yiu *Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.ORCID 0009-0004-9106-9974
Sara Fallah *Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.ORCID 0009-0002-1755-2656
Kirsten J MeyerDepartment of Biochemistry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Emily PuumalaDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Yunjin LeeDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Haley L ZubykDavid Braley Centre for Antibiotic Discovery, M. G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
Nicole RobbinsDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Justin R NodwellDepartment of Biochemistry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Jessie MacAlpineDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0001-5367-9043
Leah E CowenDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0001-5797-0110

Funding

CIHR FDN-154288CIHR MID-406688
6 · The paper itself

Abstract

Antimicrobials are a pillar of modern medicine, yet our limited arsenal of antibiotics and antifungals is currently threatened by widespread drug resistance. Ongoing efforts are focused on developing strategies to identify compounds that enhance the efficacy of current antimicrobials and develop novel, resistance-evasive therapeutic strategies. In this study, we characterized microbial isolates from two distinct environments to identify those that exhibit antimicrobial activity alone and in combination with current antimicrobials: (i) oral isolates from domesticated animals and (ii) environmental IMPORTANCE: The emergence and spread of antimicrobial resistance presents a global health challenge. As such, researchers are focused on developing pipelines to discover novel antimicrobials. In this study, we screened two distinct collections of microbes for antimicrobial activity. First, we collected bacterial and fungal isolates from the oral cavities of domesticated dogs and cats and identified these isolates using 16S (bacteria) and ITS (fungi) sequencing. Follow-up analyses confirmed that some conditioned media from bacterial isolates had antibacterial activity against

Indexed as

Anti-Bacterial AgentsAntifungal AgentsAnti-Infective AgentsBacteriaEnvironmental MicrobiologyFungiMouthStreptomycesAnimalsCandida albicansCatsDogsEscherichia coliMicrobial Sensitivity TestsAnti-Bacterial AgentsAntifungal AgentsAnti-Infective AgentsantimicrobialsCandida albicansCanis familiarisdrug combinationsEscherichia coliFelis catusresistanceStreptomyces

Identifiers

PMID40227049
PMCPMC12108073

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.