Evidence map›Paper›PMID 40226941›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2025

Binuclear Lanthanide Complexes as Magnetic Resonance and Optical Imaging Probes for Redox Sensing.

Charlie H Simms, Daniel Kovacs, Lina Hacker, Euan T Sarson, Daria Sokolova, Kirsten E Christensen, Alexandr Khrapichev, Louise A W Martin, Kylie Vincent, Stuart J Conway and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Charlie H SimmsDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.ORCID https://orcid.org/0000-0003-0675-2388
Daniel KovacsDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.
Lina HackerDepartment of Oncology, University of Oxford, Oxford, OX3 7DQ, UK.
Euan T SarsonDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.ORCID https://orcid.org/0009-0008-5023-3570
Daria SokolovaDepartment of Chemistry, Inorganic Chemistry Laboratory, University of Oxford, South Parks Road, Oxford, OX1 3QR, UK.ORCID https://orcid.org/0000-0003-0357-6171
Kirsten E ChristensenDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.ORCID https://orcid.org/0000-0003-1683-2066
Alexandr KhrapichevDepartment of Oncology, University of Oxford, Oxford, OX3 7DQ, UK.
Louise A W MartinDepartment of Oncology, University of Oxford, Oxford, OX3 7DQ, UK.
Kylie VincentDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.ORCID https://orcid.org/0000-0001-6444-9382
Stuart J ConwayDepartment of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Box 951569, Los Angeles, CA, 90095-1569, USA.ORCID https://orcid.org/0000-0002-5148-117X
Ester M HammondDepartment of Oncology, University of Oxford, Oxford, OX3 7DQ, UK.ORCID https://orcid.org/0000-0002-2335-3146
Matthew J LangtonDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.ORCID https://orcid.org/0000-0003-1555-3479
Stephen FaulknerDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.ORCID https://orcid.org/0000-0003-1878-5857

Funding

Cancer Research UK C6078/A28736Engineering and Physical Sciences Research Council EP/S023828/1H2020 European Research Council CoG-819580Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung P500PN_214322
6 · The paper itself

Abstract

We report a family of lanthanide(III) complexes that act as redox probes via both magnetic resonance (MR) and luminescence outputs. The ligands are functionalized with nitro, azobenzene and azide groups which are reduced to a common aniline product, and each responds to both chemical and biocatalytic reductive conditions at different cathodic onset potentials. By judicious choice of complexed Ln(III), the probes can be optimized either for use in MR imaging (Ln = Gd), or as highly efficient turn-on luminescence probes (Ln = Tb). The Tb(III) analogues are essentially nonemissive, until reductive generation of the aniline affords a complex which when excited by visible light (488 nm) emits green light with a quantum yield of 45% and millisecond long luminescent lifetimes (ms). The tunable redox response and imaging modalities of these versatile complexes have the potential to open up new approaches to redox sensing, such as the imaging of hypoxic environments in biology.

Indexed as

luminescencemagnetic resonanceopticalredoxsensing

Identifiers

PMID40226941
PMCPMC12117176

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.