Evidence map›Paper›PMID 40226937›Full record

ReviewPathology international2025

The Role of Artificial Intelligence in the Evaluation of Prostate Pathology.

Lars Egevad, Andrea Camilloni, Brett Delahunt, Hemamali Samaratunga, Martin Eklund, Kimmo Kartasalo

Abstract readReview
In one paragraph

Review in Pathology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lars EgevadDepartment of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-8531-222X
Andrea CamilloniDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Brett DelahuntDepartment of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Hemamali SamaratungaAquesta Pathology and University of Queensland School of Medicine, Brisbane, Queensland, Australia.
Martin EklundDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Kimmo KartasaloSciLifeLab, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Funding

L.E. was funded by grants from The Swedish Cancer Foundation (Grant No. CAN 20 1358 PjFs and 23 2641Pj) and The Stockholm Cancer Society (Grant No. 204043). K.K. received funding from the SciLifeLab & Wallenberg Data Driven Life Science Program (KAW 2024.0159), David and Astrid Hägelen Foundation, Instrumentarium Science Foundation, KAUTE Foundation, Karolinska Institute Research Foundation, Orion Research Foundation, and Oskar Huttunen Foundation.
6 · The paper itself

Abstract

Artificial intelligence (AI) is an emerging tool in diagnostic pathology, including prostate pathology. This review summarizes the possibilities offered by AI and also discusses the challenges and risks. AI has the potential to assist in the diagnosis and grading of prostate cancer. Diagnostic safety can be enhanced by avoiding the accidental underdiagnosis of small lesions. Another possible benefit is a greater degree of standardization of grading. AI for clinical use needs to be trained on large, high-quality data sets that have been assessed by experienced pathologists. A problem with the use of AI in prostate pathology is the plethora of benign mimics of prostate cancer and morphological variants of cancer that are too unusual to allow sufficient training of AI. AI systems need to be able to account for variations in local routines for cutting, staining, and scanning of slides. We also need to be aware of the risk that users will rely too much on the output of an AI system, leading to diagnostic errors and loss of clinical competence. The reporting pathologist must ultimately be responsible for accepting or rejecting the diagnosis proposed by AI.

Indexed as

Artificial IntelligenceProstateProstatic NeoplasmsHumansMaleNeoplasm Gradingartificial intelligencediagnosisgradingpathologyprostate cancer

Identifiers

PMID40226937
PMCPMC12101047

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.