Evidence map›Paper›PMID 40226883›Full record

ArticleSleep2025

Late-life disability may increase with more frequent insomnia symptoms and sleep medications use over time.

Tuo-Yu Chen, Soomi Lee, Orfeu M Buxton

Abstract read
In one paragraph

Article in Sleep, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Effects ofJournal of microbiology and biotechnology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tuo-Yu ChenGlobal Health and Health Security, College of Public Health, Taipei Medical University, Taipei, Taiwan.ORCID 0000-0003-4127-7578
Soomi LeeDepartment of Human Development and Family Studies, Center for Healthy Aging, Pennsylvania State University, University Park, PA, USA.ORCID 0000-0002-7623-3770
Orfeu M BuxtonDepartment of Biobehavioral Health, Pennsylvania State University, University Park, PA, USA.ORCID 0000-0001-5057-633X

Funding

Business and regulatory development for Integrating sleep enhancement technology into clinical practiceR44AG056250 · NIA · PROACTIVE LIFE, INC. · PI GARTENBERG, DANIEL · 2020 to 2022
$2.5M
Sleep, Pain, Active Social Life, and Inflammation (SPAI)R01HL163226 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI LYNN M. MARTIRE · 2023 to 2026
$2.1M
Non-pharmacological improvement of sleep structure in older peopleR43AG056250 · NIA · MOBILE SLEEP TECHNOLOGIES, LLC · PI GARTENBERG, DANIEL, GERASHCHENKO, DMITRY · 2017 to 2018
$696k
Georgia State University and Harvard Chan School of Public HealthNational Science and Technology Council, Taiwan 111-2314-B-038-054National Science and Technology Council, Taiwan 112-2314-B-038-074-MY3New York UniversityNHLBI NIH HHS R01 HL163226NIA NIH HHS R43 AG056250NIA NIH HHS R44 AG056250Penn State from Mobile Sleep Technologies NIH/NIA SBIR R43-AG056250Penn State from Mobile Sleep Technologies NSF/STTR #1622766Penn State from Mobile Sleep Technologies R44-AG056250Tufts School of Dental MedicineUniversity of MiamiUniversity of Utah, University of Arizona
6 · The paper itself

Abstract

STUDY

objectivesThis study investigated whether disability status increased with the frequency of insomnia symptoms and sleep medication usage over a 5-year period and whether frequent use of sleep medication modified the longitudinal effects of insomnia symptoms on disability among community-dwelling older adults.

methodsData were from the National Health and Aging Trends Study (2011-2015; n = 6722). Disability was assessed with a validated disability index. Insomnia symptoms were assessed by the average frequency of longer sleep onset latency and trouble staying asleep. General sleep medication usage frequency was assessed. Multilevel modeling was used to analyze the data, considering health status, demographic information, and risky health behavior.

resultsIn the conditional growth model, for every one-unit higher in the frequency of insomnia symptoms and sleep medication usage, disability scores increased by 0.20 (SE = .02, p < .001) and 0.19 (SE = .02, p < .001) every year, respectively, adjusting for covariates. Moreover, the frequency of sleep medication usage influenced the relationship between insomnia symptoms and disability. Specifically, more frequent insomnia symptoms were associated with higher disability scores, and using sleep medications more often led to an even greater increase in disability scores than insomnia symptoms alone.

conclusionsDisability increased with more frequent insomnia symptoms and more frequent sleep medication usage each year. More frequent sleep medication usage has detrimental implications on disability beyond insomnia symptoms. Treating insomnia and managing sleep medication properly may help prevent disability among older adults.

Indexed as

Hypnotics and SedativesPersons with DisabilitiesSleep Initiation and Maintenance DisordersAgedAged, 80 and overDisability EvaluationFemaleHumansIndependent LivingLongitudinal StudiesMaleMiddle AgedHypnotics and Sedativesdisabilityinsomnia symptomsmultilevel modelingsleep medications

Identifiers

PMID40226883
PMCPMC12720211

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.