ArticleOrganic letters2025
Synthesis of Dithioester Derivatives by Base-Mediated Fragmentation of 1,3-Dithiolanes.
Article in Organic letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Lewis Acid-Catalyzed Cascade Ring Expansion and Intramolecular Friedel-Crafts Type Cyclization of α-Dithioacetyl Propargyl Alcohols: Access toThe Journal of organic chemistry · 2026Article
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Authors and funding
9 authors.
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Abstract
Dithioesters are important agents for chain transfer in polymer chemistry and precursors in the synthesis of heterocycles. Straightforward approaches to their synthesis are therefore in demand. Outlined herein is a method to access such compounds in one-pot. 2-Aryl-1,3-dithiolanes undergo ring fragmentation with LiHMDS in CPME to generate aryl-dithiocarboxylates in 5 min at 100 °C. These anions are subsequently captured in the second step by addition of various alkyl halides and diaryliodonium salts to furnish a large library of dithioesters in good yields. The method can be also employed in a one-pot, one-step manner for alkyl bromides and allows the synthesis of dithioesters in gram scale.
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