Evidence map›Paper›PMID 40226806›Full record

ArticleInformation (Basel)2025

Multimodal Brain Growth Patterns: Insights from Canonical Correlation Analysis and Deep Canonical Correlation Analysis with Auto-Encoder.

Ram Sapkota, Bishal Thapaliya, Bhaskar Ray, Pranav Suresh, Jingyu Liu

Abstract read
In one paragraph

Article in Information (Basel), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Multimodal Fusion of Structural and Diffusion MRI for Intelligence Prediction.Proceedings. IEEE Southwest Symposium on Image Analysis and Interpretation · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ram SapkotaTranslational Research in Neuroimaging and Data Science (TReNDS) Center, Georgia State University, Atlanta, GA 30303, USA.
Bishal ThapaliyaTranslational Research in Neuroimaging and Data Science (TReNDS) Center, Georgia State University, Atlanta, GA 30303, USA.
Bhaskar RayTranslational Research in Neuroimaging and Data Science (TReNDS) Center, Georgia State University, Atlanta, GA 30303, USA.
Pranav SureshTranslational Research in Neuroimaging and Data Science (TReNDS) Center, Georgia State University, Atlanta, GA 30303, USA.
Jingyu LiuTranslational Research in Neuroimaging and Data Science (TReNDS) Center, Georgia State University, Atlanta, GA 30303, USA.ORCID 0000-0002-1724-7523

Funding

Frontal-thalamo-cerebellar circuitry of attention deficit via imaging-genetic-environmental analysesR01MH130595 · NIMH · GEORGIA STATE UNIVERSITY · PI Shihao Ji, Jingyu Liu · 2023 to 2026
$1.4M
NIMH NIH HHS R01 MH130595
6 · The paper itself

Abstract

Today's advancements in neuroimaging have been pivotal in enhancing our understanding of brain development and function using various MRI techniques. This study utilizes images from T1-weighted imaging and diffusion-weighted imaging to identify gray matter and white matter coherent growth patterns within 2 years from 9-10-year-old participants in the Adolescent Brain Cognitive Development (ABCD) Study. The motivation behind this investigation lies in the need to comprehend the intricate processes of brain development during adolescence, a critical period characterized by significant cognitive maturation and behavioral change. While traditional methods like canonical correlation analysis (CCA) capture the linear interactions of brain regions, a deep canonical correlation analysis with an autoencoder (DCCAE) nonlinearly extracts brain patterns. The study involves a comparative analysis of changes in gray and white matter over two years, exploring their interrelation based on correlation scores, extracting significant features using both CCA and DCCAE methodologies, and finding an association between the extracted features with cognition and the Child Behavior Checklist. The results show that both CCA and DCCAE components identified similar brain regions associated with cognition and behavior, indicating that brain growth patterns over this two-year period are linear. The variance explained by CCA and DCCAE components for cognition and behavior suggests that brain growth patterns better account for cognitive maturation compared to behavioral changes. This research advances our understanding of neuroimaging analysis and provides valuable insights into the nuanced dynamics of brain development during adolescence.

Indexed as

brain developmentCCADCCAEmultimodal

Identifiers

PMID40226806
PMCPMC11990250

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.