Evidence map›Paper›PMID 40226707›Full record

ArticleDepression and anxiety2024

Shared and Unique Genetic Links between Neuroticism and Gastrointestinal Tract Diseases.

Ye Tian, Jing Zi, Yifan Hu, Yaxian Zeng, Haoqi Li, Hang Luo, Jingyuan Xiong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Depression and anxiety, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. BMJ open ophthalmology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ye TianDepartment of Occupational and Environmental Health, Healthy Food Evaluation Research Center, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
Jing ZiDepartment of Occupational and Environmental Health, Healthy Food Evaluation Research Center, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
Yifan HuDepartment of Occupational and Environmental Health, Healthy Food Evaluation Research Center, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
Yaxian ZengDepartment of Occupational and Environmental Health, Healthy Food Evaluation Research Center, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
Haoqi LiDepartment of Occupational and Environmental Health, Healthy Food Evaluation Research Center, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
Hang LuoDepartment of Occupational and Environmental Health, Healthy Food Evaluation Research Center, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
Jingyuan XiongDepartment of Occupational and Environmental Health, Healthy Food Evaluation Research Center, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.ORCID 0000-0001-9354-862X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Association between neuroticism and gastrointestinal tract (GIT) diseases may not be attributable to the genetic overlaps between neuroticism and psychiatric disorders. We aim to explore the genetic links and mechanisms of neuroticism and GIT diseases. Materials and Methods: We obtained European genome-wide association data of neuroticism ( Results: Neuroticism and its subclusters are associated with most GIT diseases (15 of 18 trait-pairs). GERD and PUD were highly correlated with depressed affect. We identified pleiotropic loci 11q23.2 (mapped gene: Conclusion: Our findings document the genetic links between neuroticism and six GIT diseases, highlighting the genetic overlaps and heterogeneity between neuroticism and psychiatric disorders in the context of gastrointestinal disorders. Both the shared and unique pleiotropic loci identified between neuroticism and different GIT diseases could facilitate mechanistic understandings and may stimulate further translational implications.

Indexed as

Gastrointestinal DiseasesNeuroticismFemaleGastroesophageal RefluxGenome-Wide Association StudyHumansInflammatory Bowel DiseasesIrritable Bowel SyndromeMale

Identifiers

PMID40226707
PMCPMC11919111

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.