Evidence map›Paper›PMID 40226504›Full record

ArticleEFSA journal. European Food Safety Authority2025

Efficacy of a feed additive consisting of guanidinoacetic acid (Creamino®) for weaned piglets and pigs for fattening in water for drinking (Alzchem Trostberg GmbH).

EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Roberto Edoardo Villa, Giovanna Azimonti, Eleftherios Bonos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Ronette Gehring, Boet Glandorf, Maryline Kouba and 10 more

Abstract read
In one paragraph

Article in EFSA journal. European Food Safety Authority, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
Roberto Edoardo Villa
Giovanna Azimonti
Eleftherios Bonos
Henrik Christensen
Mojca Durjava
Birgit Dusemund
Ronette Gehring
Boet Glandorf
Maryline Kouba
Marta López-Alonso
Francesca Marcon
Carlo Nebbia
Alena Pechová
Miguel Prieto-Maradona
Ilen Röhe
Katerina Theodoridou
Jaume Galobart
Maria Vittoria Vettori
Alberto Navarro-Villa

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the efficacy of guanidinoacetic acid (GAA; Creamino®), intended for use as zootechnical additive (functional group: other zootechnicals - improvement of performance parameters) for weaned piglets and pigs for fattening in water for drinking. The additive is already authorised for use in feed and water for chickens for fattening and chickens reared for laying/breeding and only for feed in weaned piglets and pigs for fattening. In the previous opinion, the Panel concluded that the additive is safe for chickens for fattening, chickens reared for laying/breeding, piglets and pigs for fattening, the consumer, users and the environment under the proposed conditions of use. In the current submission, the applicant submitted considerations to support the authorisation of GAA in water for drinking for weaned piglets and pigs for fattening. The FEEDAP Panel reiterates it previous conclusion that the use of GAA in feed and water for drinking of weaned piglets and pigs for fattening has the potential to be efficacious in improving the zootechnical performance of the target animals under the proposed conditions of use (600-1200 mg GAA/kg complete feed; 200-600 mg GAA/L water).

Indexed as

Creaminoefficacyguanidinoacetic acidother zootechnicalszootechnical additives

Identifiers

PMID40226504
PMCPMC11986434

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.