Evidence map›Paper›PMID 40226502›Full record

ArticleEFSA journal. European Food Safety Authority2025

Safety and efficacy of a feed additive consisting of guanidinoacetic acid (Creamino®) for turkeys for fattening and reared for breeding (Alzchem Trostberg GmbH).

EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Roberto Edoardo Villa, Giovanna Azimonti, Eleftherios Bonos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Ronette Gehring, Boet Glandorf, Maryline Kouba and 12 more

Abstract read
In one paragraph

Article in EFSA journal. European Food Safety Authority, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
Roberto Edoardo Villa
Giovanna Azimonti
Eleftherios Bonos
Henrik Christensen
Mojca Durjava
Birgit Dusemund
Ronette Gehring
Boet Glandorf
Maryline Kouba
Marta López-Alonso
Francesca Marcon
Carlo Nebbia
Alena Pechová
Miguel Prieto-Maradona
Ilen Röhe
Katerina Theodoridou
Jaume Galobart
Jordi Ortuño Casanova
Maria Vittoria Vettori
Jordi Tarrés-Call
Alberto Navarro-Villa

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of guanidinoacetic acid (GAA) when used as zootechnical additive in feed and water for drinking for turkeys for fattening and turkeys reared for breeding, and a preparation of GAA when used in feed for the same target species. The FEEDAP Panel concluded that GAA at 1200 mg/kg complete feed or 600 mg/L water is safe for turkeys for fattening and turkeys reared for breeding. There is no concern on consumer safety resulting from the use of GAA for turkeys at the proposed conditions of use. GAA is not toxic by inhalation, not irritant to skin and eyes and not a dermal sensitiser. The FEEDAP Panel concluded that the use of GAA as feed additive is not expected to pose a risk to the environment. The use of the additive under assessment in animal nutrition at the proposed conditions of use has the potential to be efficacious in turkeys for fattening and turkeys reared for breeding. The above conclusions apply to both the active substance GAA and the preparation of GAA.

Indexed as

efficacyguanidinoacetic acidsafetyzootechnical additives

Identifiers

PMID40226502
PMCPMC11986433

What OpenQuestion holds

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LicenceCC BY-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.